Objective Foreseen ResultsThe results will consist of estimates of the risk of lung cancer in CCE/NIS by occupational medicine, air pollution and tobacco smoking.The objectives of the projects are to identify occupational risk factors of lung cancer in Countries of Central Europe (CCE) and new Independent States (NIS), to quantify the contribution of occupational factors to the lung cancer burden.The project will consist of an epidemiological case-control study, with data collection via personal interview and collection of blood and lung tissue samples. All incident cases of lung cancer in the selected areas or hospitals will be included. Controls will be selected among hospital patients undergoing minor surgical operations in the same hospitals as the cases. A detailed interview of each case and each control will be conduced either in the hospital or at home to elicit information on exposure to occupational agents and to other major known and suspected risk factors of lung cancer : tobacco smoking, passive smoking, dietary habits, residential history (to assess exposure to air pollution), family history of cancer, and personal history of X-rays and of diseases. Information on the clinical aspects of the neoplasms will be collected for cases only. Specific questionnaires will be used to elicit detailed information on job tasks and agents used in the case of employment in industries entailing exposure to known and suspected lung carcinogens. The study will be conducted in 6 areas from CCE/NIS characterized by high prevalence of industrialization.The preliminary list of agents for which exposure will be assessed includes asbestos, arsenic, chromium, nickel, polycyclic aromatic hydrocarbons, formaldehyde, strong inorganic acids, man-made mineral fibers, wood dust, dust, gas and solvents.No special measurements of air pollution will be made for this study, but existing data will be used to classify the current and historical exposures pertaining to the current and previous places of residence of each case and control.Exposure to known and suspected occupational carcinogens will be assessed via an evaluation of the questionnaire responses by a team of experts (typically an industrial hygienist, chemist and occupational physician) set up in each participating center. This involves assessing level, probably duration of exposure to each agent, together with the confidence in the assessment, for each period of employment of each case and control. Fields of science humanitieshistory and archaeologyhistorymedical and health sciencesclinical medicineoncologylung cancernatural scienceschemical sciencesinorganic chemistrytransition metalsengineering and technologyenvironmental engineeringair pollution engineeringnatural sciencesearth and related environmental sciencesenvironmental sciencespollution Programme(s) FP4-INCO - Specific research, technological development and demonstration programme in the field of cooperation with third countries and international organizations, 1994-1998 Topic(s) 01020301 - Research into occupational medicine Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INTERNATIONAL AGENCY FOR RESEARCH ON CANCER EU contribution No data Address 150,Cours Albert Thomas 150 69372 LYON France See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all FODOR JOZSEF NATIONAL PUBLIC HEALTH CENTRE Hungary EU contribution No data Address 2-6,Gyalli ut 2-6 1966 BUDAPEST See on map Total cost No data Institute of Hygiene, Public Health, Health Services and Management Romania EU contribution No data Address 1-3,Dr. Leonte Street 76256 Bucharest See on map Total cost No data LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE United Kingdom EU contribution No data Address Keppel Street WC1E 7HT LONDON See on map Total cost No data N.N. Blokhin Cancer Research Centre -Russian Academy of Medical Sciences Russia EU contribution No data Address 24,Kashirskoe Sh. 115478 Moskva See on map Total cost No data Specialized State Health Institute Slovakia EU contribution No data Address 1,Cesta K. Nemocnici 975 56 Banska Bystrica See on map Total cost No data The Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology Poland EU contribution No data Address 00 973 Warszawa See on map Total cost No data The Nofer Institute of Occupational Medicine Poland EU contribution No data Address 8,Teresy Street 90 950 Lodz See on map Total cost No data