Objective
With the aim of developing a general methodology and kinetic models for the predetermined spontaneous resolutions of racemates, the purpose of the project is
to study, in a series of both known and new conglomerates
1) crystallization using a deficiency of achiral resolving reagents such as a) conglomerator forming adducts with the compound to be resolved which, in turn, forms a crystalline conglomerate, or;
b) solubilisator favoring the increase of solubility of the compound to be resolved, the latter itself forming a crystalline conglomerate;
2) complete spontaneous transformation of a conglomerate into one enantiomer by exhaustive stirred crystallization under conditions of fast racemization in solution or melt (crystallization induced asymmetric transformation);
to study the nature of homochiral packing of chiral molecules in the crystal for some classes of organic and coordinated compounds;
to develop the directed synthesis of bis-amides and bis-nitrils including cage bis-lactones, bis-lactams, bis-ketones, bis-benzo and naphtho structures and bidentate ligands capable of homochiral self-assembling into H-bonded and metal-coordinated suprastructures in crystals and co-crystals. For some compounds we will study the possibility of racemate to conglomerate transformation by phase transition in crystal and during crystallization from solution or melt under various conditions;
to synthesize and study new chiral supramolecular structures and synthons for developing chiral drugs and materials.
The methods to be applied are: organic synthesis, chemical kinetics, chromatography, X-ray diffraction including electron deformation density, NMR including solid state, CD, VCD, and ab initio calculations.
The expected results of these studies will be important for currently developing fields such as supramolecular chemistry, crystal engineering, chirotechnology and life sciences
Topic(s)
Call for proposal
Data not availableFunding Scheme
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47057 Duisburg
Germany