Objective
Cosmonauts and astronauts are exposed to space radiation, which is very complex and not very well known with respect to its biological activities. Especially important are accelerated nuclei of high energy. In this project the following aspects will be analyzed:
Chromosomal aberrations in peripheral lymphocytes of cosmonauts. Especially dicentric chromosomes, reciprocal translocations and inversions will be studied using appropriate cytogenetic methodologies.
In human lymphocytes irradiated with accelerated nuclei in vitro chromosomal aberrations will be studied. The same types of aberrations will be analyzed as described in (1).
The influence of microgravity on radiation induced chromosomal aberrations will be studied with the help of a special bioreactor.
Special techniques like PCC will be applied to analyse chromosomal aberrations shortly after they have been induced.
The programme will help to get a better understanding of radiation effects on cosmonauts and will help to create optimal shielding and protection strategies for further missions.
Call for proposal
Data not availableFunding Scheme
Data not availableCoordinator
45117 Essen
Germany