Objective
The long term goal of this proposal is to identify the molecular-genetic factors underlying disfunction of central nervous system in set of disorders, which are characterised by both neurodegenerative and mental impairments. The Alzheimer's disease (AD) is a major cause of memory loss and, diseases, which are characterised by anticipation in successive generations, supposed to be a common cause of various neurodegenerative and neuropsychiatric disorders in adult life.
This proposal seeks funding:
to identify a novel mutations and genes for Alzheimer's disease;
to identify the genes for set of autosomal- dominant neurodegenerative / neuropsychiatric diseases with anticipations.
The tasks of this proposal will be accomplished by association analysis of DNA polymorphisms in candidate-genes, genetic linkage study with subsequent positional cloning or direct search of genes containing expanded tri-nucleotide repeats. In the context of this proposal, the isolation of proteins and genes interacted with recently discovered AD presenilin genes and the study of biology of presenilins will be undertaken in vitro and in vivo systems in order to determine novel molecular factors which might lead to cell death and neurodegeneration. Isolation and characterisation of set of such disease genes may elucidate molecular mechanisms directly involved in programmed and/or stress promoted cell death and mental and memory impairment occurring post-developmentally.
Topic(s)
Call for proposal
Data not availableFunding Scheme
Data not availableCoordinator
2610 Antwerpen
Belgium