We propose to form a consortium of cardiovascular clinicians, molecular geneticists and epidemiologists to develop molecular markers of cardiovascular disease that will be used for diagnosis and prognosis in essential hypertension and its end-organ damage. The overall aim will be to use these markers as early diagnostic tests for the identification of high-risk populations and for designing new preventive and therapeutic measures. This project will combine high fidelity phenotyping, high throughput genotyping with 5000 single nucleotide polymorphisms and sophisticated statistical strategies. We will be able to identify genes causally related to hypertension and its complications and thus improve the ability of the European Community to introduce prophylactic and therapeutics measures to reduce the epidemic of cardiovascular disease.
Funding SchemeCSC - Cost-sharing contracts
3000 Louvain / Leuven
E1 4NS London