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Improved healthcare for patients with primary antibody deficiencies through new strategies elucidating their pathophysiology (IMPAD)

Objective

Primary antibody deficiencies like common variable immunodeficiency, IgA-deficiency and the non-X-linked hyper-IgM syndrome are rare, chronic diseases that are severely complicated by recurrent bacterial infections, poorly recognized in daily medical practice and expensive to treat. To understand their unknown etiologies, our multidisciplinary approach combines 10 European groups to identify the genetic origins of the deficiencies, the genetic risk factors in different European populations, the defects and changes in inter- and intracellular signalling pathways and their pathophysiological relations to immunological phenotypes and function.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITAETSKLINIKUM FREIBURG
Address
Hugstetter Strasse 55
79106 Freiburg (In Breisgau)
Germany

Participants (8)

BIOTECHNOLOGIE INSTITUT THURGAU
Switzerland
Address
Konstanzer Strasse 19
8274 Taegerwilen
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Campus De La Universidad Autonoma De Madrid
28049 Madrid
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
156,Rue De Vaugirard 156 - Hop. Necker-enfants Malades
75730 Paris
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
149,Rue De Sèvres 149 - Hopital Necker Enfants Malades
75015 Paris
KAROLINSKA INSTITUTE
Sweden
Address
Huddinge University Hospital
141 86 Stockholm
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Royal Free Campus, Rowland Hill Street
NW3 2PF London
UNIVERSITY OF BIELEFELD
Germany
Address
Universitatsstrasse 25
33615 Bielefeld
UNIVERSITÀ DEGLI STUDI DI BRESCIA
Italy
Address
Piazzale Spedali Civili 1
25123 Brescia