We propose an integrated approach to study the molecular basis of cell communication processes generating neural diversity in forebrain development in chick, mouse and zebra fish embryos. Our ultimate goal is to understand the signals that define the variety of neural cell types in the forebrain. We will focus on understanding the zone limiting intrathalamica (sly), an important signalling centre recently discovered in the forebrain. A combination of experimental embryology and molecular techniques exploiting the different strengths of each model organism will be used to study the development, signalling activity and interactions of the sly. Isolation and functional studies of key genes will determine the role of these genes in the sly, and in forebrain development more generally. This understanding will form an essential basis for designing repair strategies for the damaged or deceased human brain.
Funding SchemeCSC - Cost-sharing contracts
SE1 1UL London
03550 San Juan De Alicante