Objective Hepatitis C virus (HCV) infections lead to liver cirrhosis and hepatocellular carcinoma. Currently no efficient drug or vaccine is available. A team of 6 European laboratories from D, F, PL will synthesise and investigate the psycho-chemical and biological properties of a broad range of new modified nucleoside derivatives, guanine, trampoline and anthracycline analogy and their prod rugs, potential inhibitors of HCV RNA helices, a novel and promising target for anti- HCV therapy. The interactions of analogy with HCV helices will be investigated with the use of kinetic methods, crystallography, and multidimensional NMR and CD spectroscopy. Inhibitory activity against HCV helices will be verified in vitro in HCV-infected human macrophages, in human hepatocytes and in yeast cell system. This research should deliver new anti-HCV drugs and may improve the quality of life of millions of HCV-infected patients. Fields of science medical and health scienceshealth sciencesinfectious diseasesRNA viruseshepatitis Cmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesclinical medicinehepatologynatural sciencesbiological sciencesgeneticsRNAmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES EU contribution No data Address Pawinskiego 5a 02-106 WARSZAWA Poland See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all BERNHARD NOCHT INSTITUT FUER TROPENMEDIZIN Germany EU contribution No data Address Bernhard-Nocht-Strasse 74 HAMBURG See on map Total cost No data FREIE UNIVERSITAET BERLIN Germany EU contribution No data Address Takustrasse 6 14195 Berlin See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Cours Albert Thomas 151 ADR 5 - Rhône-Alpes, Auve 69424 LYON See on map Total cost No data INSTITUTE OF ORGANIC INDUSTRY Poland EU contribution No data Address Doswiadczalna 27 43 200 PSZCZYNA See on map Total cost No data INSTYTUT MEDYCYNY DOSWIADCZALNEJ I KLINICZNEJ POLSKIEJ AKADEMII NAUK Poland EU contribution No data Address Pawinskiego 5 02 106 WARSZAWA See on map Total cost No data