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THYROXINE IN HUMAN SERUM

Objective



Thyroxine is a hormone secreted by the thyroid gland. It controls a great many metabolic processes in the body. In the newborn, it has been shown to play a key role for the growth and development of the brain. In the field of hormonology, the determination of serum thyroxine is amongst the most frequent tests.

The project comprises the set-up of an isotope dilution - mass spectrometry method (ID-MS), including the preparation of labelled thyroxine. Three batches of human serum, each of them corresponding to a particular thyroxine level will be certified. Thyroxine levels selected are those found in hypothyroid subjects, normal individuals and hyperthyroid patients respectively.

STATUS

Methodological developments are completed. Three laboratories are using ID-MS for the determination of serum thyroxine. Two intercomparison exercises have been carried out. Certification is expected in 1992.

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Coordinator

Rheinische Friedrich-Wilhelms-Universität Bonn
Address
Sigmund-freud-straße 25
53127 Bonn
Germany

Participants (2)

National Institute for Biological Standards and Control (NIBSC)
United Kingdom
Address
Blanche Lane South Mimms
EN6 3QG Potters Bar
Rijksuniversiteit Gent
Belgium