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A Treatment-Oriented Research Project of NCL Disorders as a Major Cause of Dementia in Childhood

Objective

"The DEM-CHILD project focusses on the main cause for childhood dementia in Europe, the neuronal ceroid lipofuscinoses (NCLs). The NCLs are neurodegenerative diseases characterized by dementia, blindness, epilepsy and physical decline leading to an early death of the patients. Since no cure is currently available, these disorders represent a serious social, medical, and economic challenge.
To date, eight NCL genes have been characterised. There is evidence suggesting that further gene loci remain to be identified. NCLs are under-diagnosed in many countries around the world as there is an overall lack of research, early diagnosis, treatment and expert availability. Furthermore, due to their broad genetic heterogeneity it is difficult to collect large numbers of genetically similar patients. As such, large therapeutic studies required for advances in treatment are difficult to initiate. The DEM-CHILD project will combine the expertise of (i) recognized European research teams with (ii) high-technology SMEs, and will (iii) collaborate with Indian experts on the following objectives:
(1) High-technology SMEs will develop innovative cost- and time-effective testing and screening methods for all NCLs in order to ensure early diagnosis and thereby prevention.
(2) DEM-CHILD will collect the world’s largest, clinically and genetically best characterised set of NCL patients in order to study disease prevalence and precisely describe the natural history of the NCLs leading to the development of an evaluation tool for experimental therapy studies.
(3) Novel biomarkers and modifiers of NCL will be identified to support the development of innovative therapies.
(4) Focussing on the development of therapies for NCLs caused by mutations in intracellular transmembrane proteins, two complementary therapeutic strategies will be used and compared in eye and brain of mouse models: a) viral-mediated gene transfer and b) neural stem cell-mediated delivery of neuroprotective factors."

Call for proposal

FP7-HEALTH-2011-single-stage
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Coordinator

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Address
Martinistrasse 52
20251 Hamburg
Germany

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Schulz (Dr.)
EU contribution
€ 876 160

Participants (12)

SAMFUNDET FOLKHALSAN I SVENSKA FINLAND RF
Finland
EU contribution
€ 542 192
Address
Topeliusgatan 20
00250 Helsinki

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Activity type
Research Organisations
Administrative Contact
Christer Holmström (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 401 347
Address
Gower Street
WC1E 6BT London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 357 120
Address
Via Dell Artigliere 8
37129 Verona

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Manuela Calderara (Dr.)
POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH
India
EU contribution
€ 64 828
Address
Sector 12, Post Graduate Institute Of Medical Education And Research
160012 Chandigarh

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Activity type
Research Organisations
Administrative Contact
Poonam Manchanda (Ms.)
IMAGENES GMBH
Germany
EU contribution
€ 12 610
Address
Robert Roessle Strasse 10
13125 Berlin

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Stock (Mr.)
ZENTRUM FUR STOFFWECHSELDIAGNOSTIKREUTLINGEN GMBH
Germany
EU contribution
€ 90 072
Address
Worthstrasse 47
72764 Reutlingen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Herbert Korall (Dr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 199 992
Address
Strand
WC2R 2LS London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
GUYS AND ST THOMAS' NHS FOUNDATIONTRUST
United Kingdom
EU contribution
€ 34 532
Address
Westminster Bridge Road
SE1 7EH London

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Activity type
Research Organisations
Administrative Contact
Jeremy Brinley-Codd (Mr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG
Germany
EU contribution
€ 170 937
Address
Oskar Von Miller Ring 29
80333 Muenchen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Mrs.)
CRM COASTAL RESEARCH AND MANAGEMENT GESELLSCHAFT FUR KUSTENFORSCHUNG UND MANAGEMENT MIT HAFTUNGSBESCHRANKUNG GBR
Germany
EU contribution
€ 52 155
Address
Tiessenkai 12
24159 Kiel

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christian Koch (Mr.)
Source Bioscience plc
United Kingdom
EU contribution
€ 146 850
Address
Orchard Place, Business Park 1
NG8 6PX Nottingham

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nick Cox
STEINBEIS GMBH & CO KG FUR TECHNOLOGIE TRANSFER
Germany
EU contribution
€ 50 000
Address
Adornostrasse 8
70599 Stuttgart

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Susanne Hartner