Objectif "The DEM-CHILD project focusses on the main cause for childhood dementia in Europe, the neuronal ceroid lipofuscinoses (NCLs). The NCLs are neurodegenerative diseases characterized by dementia, blindness, epilepsy and physical decline leading to an early death of the patients. Since no cure is currently available, these disorders represent a serious social, medical, and economic challenge.To date, eight NCL genes have been characterised. There is evidence suggesting that further gene loci remain to be identified. NCLs are under-diagnosed in many countries around the world as there is an overall lack of research, early diagnosis, treatment and expert availability. Furthermore, due to their broad genetic heterogeneity it is difficult to collect large numbers of genetically similar patients. As such, large therapeutic studies required for advances in treatment are difficult to initiate. The DEM-CHILD project will combine the expertise of (i) recognized European research teams with (ii) high-technology SMEs, and will (iii) collaborate with Indian experts on the following objectives:(1) High-technology SMEs will develop innovative cost- and time-effective testing and screening methods for all NCLs in order to ensure early diagnosis and thereby prevention.(2) DEM-CHILD will collect the world’s largest, clinically and genetically best characterised set of NCL patients in order to study disease prevalence and precisely describe the natural history of the NCLs leading to the development of an evaluation tool for experimental therapy studies.(3) Novel biomarkers and modifiers of NCL will be identified to support the development of innovative therapies.(4) Focussing on the development of therapies for NCLs caused by mutations in intracellular transmembrane proteins, two complementary therapeutic strategies will be used and compared in eye and brain of mouse models: a) viral-mediated gene transfer and b) neural stem cell-mediated delivery of neuroprotective factors." Champ scientifique medical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesmedical biotechnologygenetic engineeringgene therapyhumanitieshistory and archaeologyhistorymedical and health sciencesbasic medicineneurologydementianatural sciencesbiological sciencesgeneticsmutation Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2011.2.2.1-4 - Creating clinical and molecular tools for experimental therapy of paediatric neurodegenerative disorders causing childhood dementia in Europe and India Appel à propositions FP7-HEALTH-2011-single-stage Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Contribution de l’UE € 876 160,00 Adresse Martinistrasse 52 20251 Hamburg Allemagne Voir sur la carte Région Hamburg Hamburg Hamburg Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (12) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire SAMFUNDET FOLKHALSAN I SVENSKA FINLAND RF Finlande Contribution de l’UE € 542 192,00 Adresse TOPELIUSGATAN 20 00250 Helsinki Voir sur la carte Région Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITY COLLEGE LONDON Contribution de l’UE € 401 347,00 Adresse GOWER STREET WC1E 6BT LONDON Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI VERONA Italie Contribution de l’UE € 357 120,00 Adresse VIA DELL ARTIGLIERE 8 37129 Verona Voir sur la carte Région Nord-Est Veneto Verona Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH Inde Contribution de l’UE € 64 828,00 Adresse SECTOR 12, POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH 160012 CHANDIGARH Voir sur la carte Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Coût total Aucune donnée IMAGENES GMBH Allemagne Contribution de l’UE € 12 610,00 Adresse ROBERT ROESSLE STRASSE 10 13125 BERLIN Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ZENTRUM FUR STOFFWECHSELDIAGNOSTIKREUTLINGEN GMBH Allemagne Contribution de l’UE € 90 072,00 Adresse WORTHSTRASSE 47 72764 REUTLINGEN Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée KING'S COLLEGE LONDON Royaume-Uni Contribution de l’UE € 199 992,00 Adresse STRAND WC2R 2LS London Voir sur la carte Région London Inner London — West Westminster Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée GUYS AND ST THOMAS' NHS FOUNDATIONTRUST Royaume-Uni Contribution de l’UE € 34 532,00 Adresse Westminster Bridge Road SE1 7EH London Voir sur la carte Région London Inner London — East Lambeth Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Allemagne Contribution de l’UE € 170 937,00 Adresse OSKAR VON MILLER RING 29 80333 Muenchen Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CRM COASTAL RESEARCH AND MANAGEMENT GESELLSCHAFT FUR KUSTENFORSCHUNG UND MANAGEMENT MIT HAFTUNGSBESCHRANKUNG GBR Allemagne Contribution de l’UE € 52 155,00 Adresse TIESSENKAI 12 24159 Kiel Voir sur la carte Région Schleswig-Holstein Schleswig-Holstein Kiel, Kreisfreie Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Source Bioscience plc Royaume-Uni Contribution de l’UE € 146 850,00 Adresse ORCHARD PLACE, BUSINESS PARK 1 NG8 6PX NOTTINGHAM Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée STEINBEIS GMBH & CO KG FUR TECHNOLOGIE TRANSFER Allemagne Contribution de l’UE € 50 000,00 Adresse ADORNOSTRASSE 8 70599 Stuttgart Voir sur la carte Région Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée
