CORDIS
EU research results

CORDIS

English EN

Resistance in Gram-Negative Organisms: Studying Intervention Strategies

Objective

Antibiotics are a mainstay of public health, but their use has increased exponentially leading to the emergence of antibiotic resistance. The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical studies, all supported by highly innovative microbiology, mathematical modelling and data-management, to determine - in the most relevant patient populations - the efficacy and effectiveness of cutting-edge interventions to reduce carriage, infection and spread of Multi-Drug Resistant Gram-negative Bacteria (MDR-GNB). All work-packages will progress science beyond the state-of-the-art in generating new and translational clinically relevant knowledge, through hypothesis-driven studies focussed on patient-centred outcomes.
The 5 clinical studies will investigate the following interventions:
•A Point-Of-Care-Testing guided management strategy to improve appropriate antibiotic prescription for uncomplicated UTI in primary care.
•Gut decolonization in outpatients with intestinal carriage of MDR-GNB.
•A “test and prescribe” strategy, based on rapid diagnostic testing of faeces for MDR-GNB to optimize antibiotic prophylaxis in colo-rectal surgery.
•Contact Isolation of patients with ESBL-producing Enterobacteriaceae in general hospital wards.
•Three Decolonization strategies in ICUs.
Seven laboratories across Europe will perform microbiological analyses, as well as unique quantitative experiments. All information will be integrated by 3 groups of mathematical modellers into highly innovative models to better understand and predict future trends and effects of interventions. The studies and analyses proposed in R-GNOSIS will generate a step-change in identifying evidence-based preventive measures and clinical guidance for primary care and hospital-based physicians and health-care authorities, to combat the spread and impact of infections caused by MDR-GNB in Europe.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Address

Heidelberglaan 100
3584 Cx Utrecht

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 4 164 036,18

Administrative Contact

E. Van Geenen (Dr.)

Participants (23)

Sort alphabetically

Sort by EU Contribution

Expand all

UNIVERSITE DE GENEVE

Switzerland

EU Contribution

€ 969 064,68

UNIVERSITEIT ANTWERPEN

Belgium

EU Contribution

€ 972 490

THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV

Israel

EU Contribution

€ 1 276 652,84

Public Health England an Executive Agency of the Dept of Health

United Kingdom

EU Contribution

€ 631,68

UNIVERSITE PARIS XII VAL DE MARNE

France

EU Contribution

€ 162 110,99

UNIVERSITE PARIS-SUD

France

EU Contribution

€ 84 942,55

CARDIFF UNIVERSITY

United Kingdom

EU Contribution

€ 936 549

UNIVERSITY OF SOUTHAMPTON

United Kingdom

EU Contribution

€ 238 905

SOCIEDAD ESPANOLA DE MEDICINA DE FAMILIA Y COMUNITARIA

Spain

EU Contribution

€ 195 808

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 756 573

UNIVERSITE PARIS DIDEROT - PARIS 7

France

DA VOLTERRA SAS

France

EU Contribution

€ 177 039,20

SERVICIO MADRILENO DE SALUD

Spain

EU Contribution

€ 385 922

STATENS SERUM INSTITUT

Denmark

EU Contribution

€ 77 268

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 392 153

ARTTIC

France

EU Contribution

€ 407 000

CHECK-POINTS HEALTH BV

Netherlands

EU Contribution

€ 48 750

GENEWAVE SAS

France

EU Contribution

€ 51 411,11

APTATECK BIO LTD

Israel

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

EU Contribution

€ 242 510

HUMFRYX S.C

Spain

EU Contribution

€ 40 482

Department of Health

United Kingdom

EU Contribution

€ 319 142,32

UNIVERSITE DE FRIBOURG

Switzerland

EU Contribution

€ 100 557,45

Project information

Grant agreement ID: 282512

Status

Closed project

  • Start date

    1 October 2011

  • End date

    31 March 2017

Funded under:

FP7-HEALTH

  • Overall budget:

    € 15 654 161,20

  • EU contribution

    € 11 999 999

Coordinated by:

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

This project is featured in...