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Evolution and Transfer of Antibiotic Resistance

Objective

Antibiotics are essential therapeutics in the treatment of bacterial infections. However, the indiscriminate use of antibiotics has led to the emergence of antibiotic resistant bacteria that pose a major threat to human health as options for treating infections by these bacteria have become limited. The evolution, emergence and spread of
antibiotic resistance genes are still only poorly understood and expanding our knowledge on these aspects will provide novel leads to combat the emergence of antibiotic resistance.

The EvoTAR consortium gathers a multi-disciplinary group of leading European researchers in the fields of antibiotic resistance, microbial genomics and mathematical modelling. In addition, three research-intensive SMEs participate in EvoTAR, two of which are involved in the development of novel approaches to minimize the emergence and spread of antibiotic resistance.

The purpose of EvoTAR is to increase the understanding of the evolution and spread of antibiotic resistance in human pathogens. EvoTAR will characterise the human reservoir of antibiotic resistance genes (“the resistome”) by investigating the dynamics and evolution of the interaction between resistant and non-resistant bacteria from
the human microbiome and the interrelations of the human resistome with non-human reservoirs of resistance genes. Novel methods will be used to quantify resistance transfer under controlled conditions in gene exchange communities. Mathematical modelling will be applied to predict gene flow between different reservoirs and to
predict future resistance trends. Novel in vitro and in vivo models will allow the study of the efficacy of novel therapeutics aimed at reducing selection and spread of antibiotic resistance.

The EvoTAR project will generate novel insights into the evolution and spread of antibiotic resistance genes and thereby create opportunities for the development of novel interventions to curb the rising tide of antibiotic resistance in human pathogens.

Call for proposal

FP7-HEALTH-2011-single-stage
See other projects for this call

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 216 200
Administrative Contact
Susan Zwaagstra (Ms.)

Participants (17)

SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 992 036
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
José Ignacio Flores Nicolás (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 758 742,88
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jiménez Arroyo (Mr.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 731 824
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marianne Wigenius (Ms.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 1 507 742,80
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Irene Taaning Johansen (Ms.)
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 706 661,93
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tom Bessems (Mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 605 581,71
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
UNIVERSITE PARIS DIDEROT - PARIS 7

Participation ended

France
Address
Rue Thomas Mann 5
75205 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Bonvalet (Ms.)
DA VOLTERRA SAS
France
EU contribution
€ 362 047,50
Address
Rue De Charonne 172 Le Dorian Batiment B
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Florence Sejourne (Ms.)
UNIVERSIDAD DE CANTABRIA
Spain
EU contribution
€ 523 612
Address
Avenida De Los Castros S/n
39005 Santander
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Juan José San Miguel Roncero (Mr.)
INSTITUT PASTEUR
France
EU contribution
€ 174 584
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
INSTITUTO BIOMAR SA
Spain
EU contribution
€ 306 864
Address
Calle D Parque Tecnologico De Leon Parcela M 10.4 Armunia
24009 Leon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Antonio Fernández Medarde (Dr.)
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 288 552
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maribel Rodríguez Villa (Ms.)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 1 538 694,31
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Florence Haimet (Ms.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 388 404,24
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
David Dougal (Mr.)
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 434 184
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gian Maria Rossolini (Prof.)
MICRODISH BV
Netherlands
EU contribution
€ 238 708,60
Address
Schipholweg 275
1171 PK Badhoevedorp
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Hessing (Dr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 222 952
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Alix Pillot (Ms.)