Skip to main content

Intracellular antibody Immunity

Objective

Antibodies are a critical component of immune defence but they provide purely extracellular protection – once inside a cell, a pathogen is safe. This is the view of humoral immunity that has existed for over 100 years. However, recent work in my lab has led to the discovery of a missing system of antibody-mediated immunity that takes place inside infected cells. I have identified a novel cytosolic antibody receptor (TRIM21) that binds to antibody-coated viruses after cellular infection and targets them for degradation in the proteasome. Importantly, TRIM21-mediated immunity is capable of clearing a cell of virus within hours of infection. This discovery represents a paradigm shift in how we think about viral immunity and offers the potential for new types of antiviral drugs.

This grant application outlines key experiments to determine how intracellular antibody immunity works, what it works against and how we can augment or replicate it in the treatment of disease.

Field of science

  • /natural sciences/biological sciences/microbiology/virology

Call for proposal

ERC-2011-StG_20101109
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

MEDICAL RESEARCH COUNCIL
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
United Kingdom
Activity type
Research Organisations
EU contribution
€ 1 124 340
Principal investigator
Leo James (Dr.)
Administrative Contact
Elizabeth Cutler (Ms.)

Beneficiaries (1)

MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 1 124 340
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Principal investigator
Leo James (Dr.)
Administrative Contact
Elizabeth Cutler (Ms.)