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Role of human papillomavirus infection and other co-factors in the aetiology of head and neck cancer in India and Europe

Objectif

Human papillomavirus (HPV) is responsible for approximately 25% of head and neck cancer (HNC) worldwide and appears to be associated with a better response to treatment and improved prognosis. Evidence suggests that HPV-induced HNC has steadily increased in the USA and some European countries in the last decades. However, whether this is a worldwide phenomenon and specific risk factors are associated with it remains to be proven. In addition, little is known on the natural history and risk factors of oral HPV infection. HPV-AHEAD network aims to address these and other unanswered questions on HNC etiology and epidemiology with a focus on the role of HPV. We will assemble and analyze a large collection of plasma/sera and HNC tissues from 42 centres in 16 European countries as well as HNC tissues from 7 Indian centres together with epidemiological and clinical data. HPV status in human specimens will be evaluated by different assays in central laboratories. Epidemiological studies will be conducted to establish the overall proportion and type distribution of HPV-positive HNC at different anatomical sites in European and Indian regions as well as the time trend of the proportion of HPV-positive HNC in recent decades. Using the follow-up information on HNC patients, we will further investigate whether HPV positivity confers a better prognosis and survival. We will also conduct a study in HPV-vaccinated and non-vaccinated women in order to determine risk factors and natural history of oral HPV infections. In addition, we will search for new surrogate markers for oral HPV infection to facilitate novel screening strategies. Finally, the HPV-AHEAD consortium aims to transfer technology to Indian centres as well as to develop several strategies for the training of European and Indian researchers in infections and cancers. This study will provide important insights for the screening, diagnosis, treatment and prophylaxis of HPV-associated HNC in Europe, India and elsewhere.

Champ scientifique

  • /sciences médicales et de la santé/médecine clinique/oncologie/cancer/cancer des voies aérodigestives supérieures
  • /lettres/histoire et archéologie/histoire
  • /sciences médicales et de la santé/sciences de la santé/épidémiologie

Appel à propositions

FP7-HEALTH-2011-single-stage
Voir d’autres projets de cet appel

Régime de financement

CP-FP - Small or medium-scale focused research project

Coordinateur

CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
Adresse
150 Cours Albert Thomas
69372 Lyon Cedex 08
France
Type d’activité
Other
Contribution de l’UE
€ 1 217 848,80
Contact administratif
Olaf Kelm (Dr.)

Participants (10)

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Allemagne
Contribution de l’UE
€ 424 272
Adresse
Im Neuenheimer Feld 280
69120 Heidelberg
Type d’activité
Research Organisations
Contact administratif
Bettina Crispin (Ms.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

Participation terminée

Espagne
Adresse
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Type d’activité
Research Organisations
Contact administratif
Victoria Cochrane (Ms.)
UNIVERSITEIT ANTWERPEN
Belgique
Contribution de l’UE
€ 200 004
Adresse
Prinsstraat 13
2000 Antwerpen
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Anne Adams (Ms.)
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italie
Contribution de l’UE
€ 217 800
Adresse
Via Filodrammatici 10
20121 Milano
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Ilaria Foti (Ms.)
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
Contribution de l’UE
€ 149 960
Adresse
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Georgia Petridou (Ms.)
DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE
Allemagne
Contribution de l’UE
€ 199 285
Adresse
Arthur-scheunert-allee 114-116
14558 Nuthetal
Type d’activité
Research Organisations
Contact administratif
Judith Schaefer (Dr.)
UNIVERSITATSKLINIKUM HEIDELBERG
Allemagne
Contribution de l’UE
€ 181 800
Adresse
Im Neuenheimer Feld 672
69120 Heidelberg
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Thorsten Brietz (Mr.)
RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY
Inde
Contribution de l’UE
€ 110 000
Adresse
Millenium Parkway Jagathy
695 014 Thiruvananthapuram
Type d’activité
Research Organisations
Contact administratif
Rajan Panicker (Mr.)
ROCHE MTM LABORATORIES AG
Allemagne
Contribution de l’UE
€ 98 018,20
Adresse
Im Neuenheimer Feld 583
69120 Heidelberg
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Karin Mueller (Mrs.)
INSTITUT CATALA D'ONCOLOGIA
Espagne
Contribution de l’UE
€ 200 958
Adresse
Av Gran Via De L'hospitalet 199-203
08908 L'hospitalet Del Llobregat
Type d’activité
Research Organisations
Contact administratif
Cristina Rajo Anadón (Ms.)