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Cardiovascular Risk from Exposure to Low-dose and Low-dose-rate Ionizing Radiation

Objective

Epidemiological evidence has established a link between cardiovascular disease and exposure of the heart and major vessels to doses above 500mGy. At lower doses the evidence for a detrimental effect is inconclusive. In part, this is due to the lack of appropriate epidemiological studies, coupled with lack of knowledge of the processes involved that is needed for construction of mathematical models. The ProCardio consortium will study cardiovascular outcomes in childhood cancer survivors where the radiation doses given to the heart are available. These data will be interrogated using new mathematical models developed from the data from our molecular and biological studies. These will use state-of-the-art technologies to map cardiovascular changes after photon irradiation at both low doses and low dose rates. This will be complemented by comparative studies using high LET irradiation. We will apply an integrative approach to combine transcriptional (mRNA and miRNA) and translational (proteomics) studies to understand the disease processes. High throughput proteomics (ICPL, SILAC and label-free analysis) will be used to identify new biomarkers of radiation-induced cardiovascular disease for future molecular epidemiological studies. These will be validated using the archives of cardiovascular tissue samples from the Mayak facility.

Field of science

  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /social sciences/media and communications/library science/archives

Call for proposal

FP7-Fission-2011
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Germany
Activity type
Research Organisations
EU contribution
€ 679 796
Administrative Contact
Jürgen Ertel (Dr.)

Participants (12)

FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL
Spain
EU contribution
€ 218 800
Address
Calle Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Joana Porcel (Ms.)
INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 269 560
Address
Rue Camille Desmoulins 39
94805 Villejuif
Activity type
Research Organisations
Administrative Contact
Arnauld Forest (Mr.)
GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH
Germany
EU contribution
€ 240 000
Address
Planckstrasse 1
64291 Darmstadt
Activity type
Other
Administrative Contact
Doris Scholz (Ms.)
Public Health England an Executive Agency of the Dept of Health

Participation ended

United Kingdom
EU contribution
€ 76 338,04
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Anne Dempsey (Ms.)
AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Italy
EU contribution
€ 184 995
Address
Lungotevere Grande Ammiraglio Thaon Di Revel 76
000196 Roma
Activity type
Research Organisations
Administrative Contact
Anna Saran (Dr.)
STUDIECENTRUM VOOR KERNENERGIE / CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE
Belgium
EU contribution
€ 231 200
Address
Avenue Herrmann Debroux 40
1160 Bruxelles
Activity type
Research Organisations
Administrative Contact
Nathalie Impens (Dr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG
Germany
EU contribution
€ 229 999,60
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Ms.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 330 000
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms.)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 154 998
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
Administrative Contact
Thedo Blijdenstein (Dr.)
FEDERAL STATE UNITARY ENTERPRISE SOUTHERN URALS BIOPHYSICS INSTITUTE OF FEDERAL MEDICOBIOLOGICAL AGENCY
Russia
EU contribution
€ 200 000
Address
Ozyorskoe Shosse 19
456780 Ozyorsk
Activity type
Research Organisations
Administrative Contact
Tamara Azizova (Dr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 80 000
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Leontien Kremer (Dr.)
Department of Health
United Kingdom
EU contribution
€ 102 699,96
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Administrative Contact
Anne Dempsey (Mrs.)