CORDIS
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CORDIS

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Cardiovascular Risk from Exposure to Low-dose and Low-dose-rate Ionizing Radiation

Objective

Epidemiological evidence has established a link between cardiovascular disease and exposure of the heart and major vessels to doses above 500mGy. At lower doses the evidence for a detrimental effect is inconclusive. In part, this is due to the lack of appropriate epidemiological studies, coupled with lack of knowledge of the processes involved that is needed for construction of mathematical models. The ProCardio consortium will study cardiovascular outcomes in childhood cancer survivors where the radiation doses given to the heart are available. These data will be interrogated using new mathematical models developed from the data from our molecular and biological studies. These will use state-of-the-art technologies to map cardiovascular changes after photon irradiation at both low doses and low dose rates. This will be complemented by comparative studies using high LET irradiation. We will apply an integrative approach to combine transcriptional (mRNA and miRNA) and translational (proteomics) studies to understand the disease processes. High throughput proteomics (ICPL, SILAC and label-free analysis) will be used to identify new biomarkers of radiation-induced cardiovascular disease for future molecular epidemiological studies. These will be validated using the archives of cardiovascular tissue samples from the Mayak facility.
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Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Address

Ingolstadter Landstrasse 1
85764 Neuherberg

Germany

Activity type

Research Organisations

EU Contribution

€ 679 796

Administrative Contact

Jürgen Ertel (Dr.)

Participants (12)

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FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

Spain

EU Contribution

€ 218 800

INSTITUT GUSTAVE ROUSSY

France

EU Contribution

€ 269 560

GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH

Germany

EU Contribution

€ 240 000

Public Health England an Executive Agency of the Dept of Health

United Kingdom

EU Contribution

€ 76 338,04

AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE

Italy

EU Contribution

€ 184 995

STUDIECENTRUM VOOR KERNENERGIE / CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE

Belgium

EU Contribution

€ 231 200

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Germany

EU Contribution

€ 229 999,60

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

EU Contribution

€ 330 000

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

EU Contribution

€ 154 998

FEDERAL STATE UNITARY ENTERPRISE SOUTHERN URALS BIOPHYSICS INSTITUTE OF FEDERAL MEDICOBIOLOGICAL AGENCY

Russia

EU Contribution

€ 200 000

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU Contribution

€ 80 000

Department of Health

United Kingdom

EU Contribution

€ 102 699,96

Project information

Grant agreement ID: 295823

Status

Closed project

  • Start date

    1 October 2011

  • End date

    31 March 2015

Funded under:

FP7-EURATOM-FISSION

  • Overall budget:

    € 5 489 075,40

  • EU contribution

    € 2 998 386,60

Coordinated by:

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany