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Multidisciplinary evaluation of the cancer risk from neutrons relative to photons using stem cells and the induction of second malignant neoplasms following paediatric radiation therapy

Objective

The ANDANTE project will investigate the relative risk of neutrons compared to photons for tumorigenesis, as a function of dose and energy. The approach will be multidisciplinary, including physics measurements and modelling, molecular biology, radiobiology, and epidemiology. The relative risk of neutrons will be studied using human and animal stem cells irradiated with either photons or neutrons in vitro and analysed for early indicators of malignant transformations. Irradiated stem cells will be transplanted into mice to investigate progression into tumours. The experimental irradiation setup will be fully characterised and modelled in order to compare predicted molecular damage with biological results, following controlled irradiation with either photons or neutrons. A corresponding predictive model of the relative risk of cancer induction from photons or neutrons following paediatric radiotherapy will be developed and tested on clinical data, as a proof of principle, leading to a proposal for a prospective epidemiological study to validate the relative risk of neutrons on humans.
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Coordinator

UNIVERSITA DEGLI STUDI DI PAVIA

Address

Strada Nuova 65
27100 Pavia

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 940 000

Administrative Contact

Maria Brunelli (Dr.)

Participants (8)

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BUNDESAMT FUER STRAHLENSCHUTZ

Germany

EU Contribution

€ 150 000

CHALMERS TEKNISKA HOEGSKOLA AB

Sweden

EU Contribution

€ 142 884

EUROPEAN SOCIETY FOR RADIOTHERAPY AND ONCOLOGY

Belgium

EU Contribution

€ 100 000

LOMA LINDA UNIVERSITY

United States

EU Contribution

€ 120 000

PAUL SCHERRER INSTITUT

Switzerland

EU Contribution

€ 350 000

TECHNISCHE UNIVERSITAET WIEN

Austria

EU Contribution

€ 17 116

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 605 000

UNIVERSITAET ROSTOCK

Germany

EU Contribution

€ 575 000

Project information

Grant agreement ID: 295970

Status

Closed project

  • Start date

    1 January 2012

  • End date

    31 December 2015

Funded under:

FP7-EURATOM-FISSION

  • Overall budget:

    € 4 465 913,98

  • EU contribution

    € 3 000 000

Coordinated by:

UNIVERSITA DEGLI STUDI DI PAVIA

Italy