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Multidisciplinary evaluation of the cancer risk from neutrons relative to photons using stem cells and the induction of second malignant neoplasms following paediatric radiation therapy

Objective

The ANDANTE project will investigate the relative risk of neutrons compared to photons for tumorigenesis, as a function of dose and energy. The approach will be multidisciplinary, including physics measurements and modelling, molecular biology, radiobiology, and epidemiology. The relative risk of neutrons will be studied using human and animal stem cells irradiated with either photons or neutrons in vitro and analysed for early indicators of malignant transformations. Irradiated stem cells will be transplanted into mice to investigate progression into tumours. The experimental irradiation setup will be fully characterised and modelled in order to compare predicted molecular damage with biological results, following controlled irradiation with either photons or neutrons. A corresponding predictive model of the relative risk of cancer induction from photons or neutrons following paediatric radiotherapy will be developed and tested on clinical data, as a proof of principle, leading to a proposal for a prospective epidemiological study to validate the relative risk of neutrons on humans.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/physical sciences/theoretical physics/particles/photons
  • /medical and health sciences/health sciences/epidemiology

Call for proposal

FP7-Fission-2011
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITA DEGLI STUDI DI PAVIA
Address
Strada Nuova 65
27100 Pavia
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 940 000
Administrative Contact
Maria Brunelli (Dr.)

Participants (8)

BUNDESAMT FUER STRAHLENSCHUTZ
Germany
EU contribution
€ 150 000
Address
Willy-brandt-strasse 5
38226 Salzgitter
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Susan Fischer (Ms.)
CHALMERS TEKNISKA HOEGSKOLA AB

Participation ended

Sweden
EU contribution
€ 142 884
Address
-
41296 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hofling Hofling (Ms.)
EUROPEAN SOCIETY FOR RADIOTHERAPY AND ONCOLOGY
Belgium
EU contribution
€ 100 000
Address
Rue Martin V 40
1200 Bruxelles
Activity type
Other
Administrative Contact
Evelyn Chimfwembe (Ms.)
LOMA LINDA UNIVERSITY
United States
EU contribution
€ 120 000
Address

92350 Loma Linda
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arlin Tueller (Mr.)
PAUL SCHERRER INSTITUT
Switzerland
EU contribution
€ 350 000
Address
Forschungstrasse 111
5232 Villigen Psi
Activity type
Research Organisations
Administrative Contact
Irene Walthert (Ms.)
TECHNISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 17 116
Address
Karlsplatz 13
1040 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephan Schneider (Dr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 605 000
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johanna M Van Apeldoorn (Ms.)
UNIVERSITAET ROSTOCK
Germany
EU contribution
€ 575 000
Address
Universitatsplatz 1
18055 Rostock
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Guido Hildebrandt (Prof.)