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Functional Genomics and Neurobiology of Epilepsy: a basis for new therapeutic strategies

Objective

Epilepsies are chronic disorders with a prevalence of 1% worldwide including Europe; they severely affect the quality of life of patients, especially of those (one third) who are drug-resistant. They are multifactorial disorders sharing common pathophysiological mechanisms among which dysfunctions in voltage-gated and ligand-gated (receptors) ion channels and alterations in structure and function of neuronal networks play a major role. This project will identify disease-causing genes and their functional role in the pathophysiology of neuronal excitability and network synchronization, using complementary advanced methods. The work will be focused on voltage-gated Na+ channels and GABAergic synaptic inhibition. Their crucial epileptogenic role is recognized for both inherited acquired epilepsies and will be investigated in animal models and human tissue with a focus on drug resistant temporal lobe epilepsy and epilepsies due to developmental cortical abnormalities. A main effort is devoted to investigate developmental aspects of epileptogenesis that account for the high frequency of epilepsies in children and for their often severe prognosis.

Strictly related to the above research lines are the pharmacological approaches by which EPICURE aims at developing more effective antiepileptic strategies, at understanding the biological bases of pharmacoresistance and at evaluating the potential of innovative therapeutic approaches based on synaptic modulation by neurotrophic factors and cell cycle kinase inhibitors. Despite the internationally recognized role of epilepsy research in Europe, the leading research groups lack a central coordination to take advantage of cross-fertilization and synergistic effects. EPICURE intends to bring together expertise from different research areas both clinical and laboratory-based with the common goal of advancing European epilepsy research to bring about novel therapeutic benefits to patients.

Call for proposal

FP6-2005-LIFESCIHEALTH-6
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Coordinator

FONDAZIONE IRCCS ISTITUTO NEUROLOGICO "CARLO BESTA"
Address
Via Giovanni Celoria 11
Milano
Italy

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Participants (32)

INSTITUT NATIONAL DE LA SANTÉ ET RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris

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UNIVERSITÀ DEGLI STUDI DI VERONA
Italy
Address
Via Dell'artigliere 8
Verona

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FRIEDRICH ALEXANDER UNIVERSITY OF ERLANGEN-NURNBERG
Germany
Address
Schlossplatz 4
Erlangen

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MAGYAR TUDOMANYOS AKADEMIA KISERLETI ORVOSTUDOMANYI KUTATOINTEZET
Hungary
Address
Szigony 43
Budapest

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UNIVERSITAETSKLINIKUM BONN
Germany
Address
Sigmund-freud Str. 25
Bonn

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CHARITÉ UNIVERSITATMEDIZIN BERLIN
Germany
Address
Luisenstr. 21-23
Berlin

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LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 2
117 Lund

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Links
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Address
Heidelberglaan 100
85600 Utrecht

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HELSINGIN YLIOPISTO
Finland
Address
Yliopistonkatu 4
Helsinki

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UNIVERSITATSKLINIKUM ULM
Germany
Address
Albert-einstein-allee 29
Ulm

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JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Saarstrasse 21
Mainz

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ISTANBUL UNIVERSITESI
Turkey
Address
Vakif Gureba Caddesi Capa
Istanbul

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FONDAZIONE ISTITUTO NEUROLOGICO NAZIONALE CASIMIRO MONDINO
Italy
Address
Via Mondino 2
Pavia

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ITÄ-SUOMEN YLIOPISTO
Finland
Address
Yliopistonranta I E
1627 Kuopio

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PHILIPPS-UNIVERSITAET MARBURG
Germany
Address
Biegenstrasse 10
Marburg

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FUNDACIÓN JIMÉNEZ DÍAZ UTE
Spain
Address
Avda. Reyes Católicos, 2
Madrid

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UNIVERSITÀ DEGLI STUDI DI FERRARA
Italy
Address
Via Savonarola 9
Ferrara

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MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
Address
Christoph Probst Platz 1
Innsbruck

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UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London

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ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
Address
Via La Masa 19
Milano

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Links
ISTITUTO GIANNINA GASLINI
Italy
Address
Largo Gerolamo Gaslini, 5
Genova

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OZ BIOSCIENCES
France
Address
Parc Scientifique Et Technologique De Luminy
Marseille

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ILERI TIP TEKNOLOJILERI DAN. HIZM. SAN. TIC. LTD. STI.
Turkey
Address
Tavukcuyolu Cad. Acun Sok. No: 54/18 / Cakmak Umraniye
Istanbul

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NSGENE A/S
Denmark
Address
154 Baltorpvej
Ballerup

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NEUROKIN SARL
France
Address
Inmed, Parc Scientifique De Luminy
Marseille

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Links
BRAINWAVE, THE IRISH EPILEPSY ASSOCIATION
Ireland
Address
249 Crumlin Road
Dublin

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CF CONSULTING FINANZIAMENTI UNIONE EUROPEA S.R.L.
Italy
Address
Via Giuseppe Mussi 1
Milano

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AZIENDA OSPEDALIERO UNIVERSITARIA MEYER
Italy
Address
Via Luca Giordano N. 7/m
Firenze

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KLINIKUM DER UNIVERSITÄT ZU KÖLN
Germany
Address
Kerpener Str. 62
Cologne

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BIOCODEX
France
Address
Avenue Galliéni 7
Gentilly

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EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
Address
Geschwister-scholl-platz 1
Tuebingen

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UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
Germany
Address
Langenbeckstr. 1
Mainz

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