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Functional Genomics and Neurobiology of Epilepsy: a basis for new therapeutic strategies

Project information

Grant agreement ID: 37315

  • Start date

    1 January 2007

  • End date

    30 June 2011

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 14 159 777

  • EU contribution

    € 9 883 259

Coordinated by:

FONDAZIONE IRCCS ISTITUTO NEUROLOGICO "CARLO BESTA"

Italy

Objective

Epilepsies are chronic disorders with a prevalence of 1% worldwide including Europe; they severely affect the quality of life of patients, especially of those (one third) who are drug-resistant. They are multifactorial disorders sharing common pathophysiological mechanisms among which dysfunctions in voltage-gated and ligand-gated (receptors) ion channels and alterations in structure and function of neuronal networks play a major role. This project will identify disease-causing genes and their functional role in the pathophysiology of neuronal excitability and network synchronization, using complementary advanced methods. The work will be focused on voltage-gated Na+ channels and GABAergic synaptic inhibition. Their crucial epileptogenic role is recognized for both inherited acquired epilepsies and will be investigated in animal models and human tissue with a focus on drug resistant temporal lobe epilepsy and epilepsies due to developmental cortical abnormalities. A main effort is devoted to investigate developmental aspects of epileptogenesis that account for the high frequency of epilepsies in children and for their often severe prognosis.

Strictly related to the above research lines are the pharmacological approaches by which EPICURE aims at developing more effective antiepileptic strategies, at understanding the biological bases of pharmacoresistance and at evaluating the potential of innovative therapeutic approaches based on synaptic modulation by neurotrophic factors and cell cycle kinase inhibitors. Despite the internationally recognized role of epilepsy research in Europe, the leading research groups lack a central coordination to take advantage of cross-fertilization and synergistic effects. EPICURE intends to bring together expertise from different research areas both clinical and laboratory-based with the common goal of advancing European epilepsy research to bring about novel therapeutic benefits to patients.

Coordinator

FONDAZIONE IRCCS ISTITUTO NEUROLOGICO "CARLO BESTA"

Address

Via Giovanni Celoria 11
Milano

Italy

Participants (32)

INSTITUT NATIONAL DE LA SANTÉ ET RECHERCHE MÉDICALE

France

UNIVERSITÀ DEGLI STUDI DI VERONA

Italy

FRIEDRICH ALEXANDER UNIVERSITY OF ERLANGEN-NURNBERG

Germany

MAGYAR TUDOMANYOS AKADEMIA KISERLETI ORVOSTUDOMANYI KUTATOINTEZET

Hungary

UNIVERSITAETSKLINIKUM BONN

Germany

CHARITÉ UNIVERSITATMEDIZIN BERLIN

Germany

LUNDS UNIVERSITET

Sweden

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

HELSINGIN YLIOPISTO

Finland

UNIVERSITATSKLINIKUM ULM

Germany

JOHANNES GUTENBERG UNIVERSITAET MAINZ

Germany

ISTANBUL UNIVERSITESI

Turkey

FONDAZIONE ISTITUTO NEUROLOGICO NAZIONALE CASIMIRO MONDINO

Italy

ITÄ-SUOMEN YLIOPISTO

Finland

PHILIPPS-UNIVERSITAET MARBURG

Germany

FUNDACIÓN JIMÉNEZ DÍAZ UTE

Spain

UNIVERSITÀ DEGLI STUDI DI FERRARA

Italy

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

UNIVERSITY COLLEGE LONDON

United Kingdom

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy

ISTITUTO GIANNINA GASLINI

Italy

OZ BIOSCIENCES

France

ILERI TIP TEKNOLOJILERI DAN. HIZM. SAN. TIC. LTD. STI.

Turkey

NSGENE A/S

Denmark

NEUROKIN SARL

France

BRAINWAVE, THE IRISH EPILEPSY ASSOCIATION

Ireland

CF CONSULTING FINANZIAMENTI UNIONE EUROPEA S.R.L.

Italy

AZIENDA OSPEDALIERO UNIVERSITARIA MEYER

Italy

KLINIKUM DER UNIVERSITÄT ZU KÖLN

Germany

BIOCODEX

France

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ

Germany

Project information

Grant agreement ID: 37315

  • Start date

    1 January 2007

  • End date

    30 June 2011

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 14 159 777

  • EU contribution

    € 9 883 259

Coordinated by:

FONDAZIONE IRCCS ISTITUTO NEUROLOGICO "CARLO BESTA"

Italy