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Developmental neurotoxicity assessment of mixtures in children

Developmental neurotoxicity assessment of mixtures in children

Objective

Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. It aims to study and evaluate environment-health relationships in children. Key elements are: development of sophisticated tools and methods for early warning and screening of compounds for neurotoxicity, to study mechanisms of disease development and the role of individual susceptibility, to improve assessment of exposures and effects, focus on combined exposures to environmental agents that can interact to enhance adverse effects and reduction of health inequalities of children through Europe. One of the main aims of DENAMIC is to develop tools and methods for neurotoxic effects of mixtures of environmental pollutants at low levels, possibly resulting in (subclinical) effects on learning (cognitive skills) and developmental disorders in children (e.g ADHD, autism spectrum disorders and anxiety disorders). A broad suite of contaminants will be included in the studies, with options to bring in new chemicals in case evidence comes up during the project. With 14 partners from ten different countries DENAMIC has a true international character. It is a comprehensive, multi-disciplinary project. Six SME’s will play a key role in the development of biotechnological screening tools. The most modern techniques in the fields of genomics, proteomics, metabolomics and transcriptomics will be applied. Dissemination will ensure the project results to arrive at policymakers' desks, and will also illustrate the subject for a scientific audience and the public. The very large network of the consortium ensures dissemination to European industries, and every other interested stakeholder.
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Coordinator

STICHTING VU

Address

De Boelelaan 1105
1081 Hv Amsterdam

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 559 968,40

Administrative Contact

Kops Yvonne (Dr.)

Participants (15)

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UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 1 070 228,50

Uppsala University

Sweden

EU Contribution

€ 747 180,80

FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE

Spain

EU Contribution

€ 649 130

SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE

Slovakia

EU Contribution

€ 65 155,25

CALLISTO PRODUCTIONS LTD

United Kingdom

EU Contribution

€ 167 000

CENTRO SUPERIOR DE INVESTIGACION EN SALUD PUBLICA

Spain

FOLKEHELSEINSTITUTTET

Norway

EU Contribution

€ 438 200

Instituto de Medicina Genómica

Spain

EU Contribution

€ 530 960

VIEW POINT SA

France

EU Contribution

€ 235 834

Proteome Sciences R&D GmbH & Co. KG

Germany

EU Contribution

€ 530 033

INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA

Romania

EU Contribution

€ 52 500

GEN-INFO ZA USLUGE D.O.O.

Croatia

EU Contribution

€ 59 856,30

Masarykova univerzita

Czechia

EU Contribution

€ 424 344,75

VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Netherlands

FUNDACION PARA EL FOMENTO DE LA INVESTIGACION SANITARIA Y BIOMEDICA DE LA COMUNITAT VALENCIANA

Spain

EU Contribution

€ 463 472,40

Project information

Grant agreement ID: 282957

Status

Closed project

  • Start date

    1 January 2012

  • End date

    31 December 2015

Funded under:

FP7-ENVIRONMENT

  • Overall budget:

    € 9 245 375,25

  • EU contribution

    € 6 993 863,40

Coordinated by:

STICHTING VU

Netherlands