Skip to main content

Transglutaminase in disease: a novel therapeutic target?

Objective

TRANSPATH is a multisectorial Network designed to facilitate the exchange of knowledge and technology between 7 leading European research teams and 3 SME partners and 2 associate SME Partners involved in basic and applied research into transglutaminase (TG) related human diseases. Its ambitions are to accelerate the development of new strategies for the treatment and diagnosis of human diseases related to transglutaminases, including metastatic cancer, neurodegeneration and celiac disease. The subject is highly relevant as deregulation of tissue transglutaminase activity is observed in a number of human diseases while the exact mechanisms are still largely unknown. The project targets this unmet clinical need. The main objectives are :1) to establish the molecular nature of the role of transglutaminases in the pathogenesis of diseases which are known to involve these multifunctional enzymes with a view to developing novel specific inhibitors and new therapeutic approaches which will have a major impact on their treatment ;2) provide an extensive cross sectorial scientific and supporting training network that will increase the capabilities of highly skilled researchers for the European biotechnology industry and academia.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

FP7-PEOPLE-2011-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

ASTON UNIVERSITY
Address
Aston Triangle
B4 7ET Birmingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 795 367,01
Administrative Contact
Martin Griffin (Prof.)

Participants (10)

STICHTING VU
Netherlands
EU contribution
€ 500 869
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne-Marie Van Dam (Dr.)
DEBRECENI EGYETEM
Hungary
EU contribution
€ 211 419
Address
Egyetem Ter 1
4032 Debrecen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
László Fésüs (Prof.)
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
EU contribution
€ 504 971
Address
Via Cracovia 50
00133 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mauro Piacentini (Prof.)
UNIVERSITETET I OSLO
Norway
EU contribution
€ 552 339
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Randi Stene (Ms.)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy
EU contribution
€ 256 903
Address
Duomo 6
13100 Vercelli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Cellerino (Prof.)
YEDITEPE UNIVERSITY VAKIF
Turkey
EU contribution
€ 202 259,99
Address
Kayisdagi Street Agustos Campus 26
81120 Istanbul
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ozge Kaya Ayvat (Ms.)
COVALAB SAS
France
EU contribution
€ 265 091,01
Address
Avenue Albert Einstein 11
69100 Villeurbanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Said El Alaoui (Dr.)
UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT
Hungary
EU contribution
€ 211 419
Address
Nagyerdei Krt 98
4032 Debrecen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gabor Zahuczky (Dr.)
X-Link Limited
United Kingdom
EU contribution
€ 239 396
Address
Biocity Nottingham, Pennyfoot Street
NG1 1GF Nottingham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Richard Neil Barnes (Dr.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Danielle Bonink (Ms.)