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Modelling nanoparticle toxicity: principles, methods, novel approaches

Objective

ModNanoTox will develop a number of well-documented and technically advanced models describing the behaviour of engineered nanoparticles in organisms and the environment. Background to these models will be a thoroughly documented database, constructed based on: (1) an advanced evaluation of physicochemical properties of nanoparticles and in silico modelling of their reactivity; and (2) assessment of the characterisation methodologies as well as toxicity protocols used to develop biological responses in toxicological studies. At the next level whole datasets will be evaluated for internal consistency and then compared with other relevant sets. The evaluation stage will be followed by development of toxicity models based at the individual organism level, using statistical and mechanistic models, in parallel with models predicting environmental fate. The toxicity and fate models will be integrated in mechanistic models to predict the long term risks of engineered nanoparticles for populations under realistic environmental conditions. The risk assessment models will be developed in close collaboration with appropriate stakeholders and end users to ensure their suitability for practical use in relevant legislative contexts.

Call for proposal

FP7-NMP-2010-EU-USA
See other projects for this call

Coordinator

THE UNIVERSITY OF BIRMINGHAM
Address
Edgbaston
B15 2TT Birmingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 382 465
Administrative Contact
May Chung (Ms.)

Participants (5)

ROSKILDE UNIVERSITET
Denmark
EU contribution
€ 227 828
Address
Universitetsvej 1
4000 Roskilde
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bjarne Clausen (Mr.)
EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ
Switzerland
EU contribution
€ 153 805
Address
Uberlandstrasse 133
8600 Dubendorf
Activity type
Other
Administrative Contact
Laura Klein (Ms.)
EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT
Switzerland
EU contribution
€ 110 191
Address
Ueberlandstrasse 129
8600 Dubendorf
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Heidi Leutwyler (Ms.)
IN SILICO TOXICOLOGY GMBH
Switzerland
EU contribution
€ 125 610
Address
Altkircherstrasse 4
4054 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christoph Helma
UNIVERSITY OF NEBRASKA
United States
Address
Holdrege Street 3835
68583 Lincoln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Suzan Lund (Ms.)