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Genetic studies of pre-eclampsia in Central Asian and European populations

Objective

Pre-eclampsia, one of the most dangerous cardiometabolic complications of pregnancy, claims the lives of 50,000 mothers and almost one million babies annually. Pre-eclampsia and other hypertensive disorders of pregnancy remain the second most common cause of maternal death. The incidence of pre-eclampsia in Central Asian countries is over twice as high as in western Europe. Inter-population differences in genetic variants may be partly responsible for variation in predisposition to the condition.
The AIMS of the InterPregGen consortium proposal are to establish sustainable and productive collaborative links between research groups in Central Asia (Kazakhstan and Uzbekistan) and Europe (Finland, Iceland, Norway, UK); and to identify and compare the genetic variants which predispose to pre-eclampsia. We shall achieve the first aim through scientific co-operation, and through training of Central Asian researchers in centres of excellence in Europe. We shall address the limited knowledge of genetic diversity in Central Asian populations by undertaking whole genome sequencing, analogous to the 1000 Genomes project. We will establish the first pre-eclampsia biobanks of DNA and plasma samples from a total of 4000 affected women, their partners and babies, and matched control samples from healthy pregnant women, in Kazakhstan and Uzbekistan. Existing genome-wide screening data, and data generated as part of this project, from a total of 10400 maternal cases and 7800 affected babies, will be used to identify pre-eclampsia susceptibility genes. We will maximise the information available by conducting meta-analyses of maternal and fetal datasets, and examining maternal-fetal gene interaction effects.
By identifying genetic variants which predispose to pre-eclampsia we will gain insights into the underlying pathological mechanisms. This will generate novel hypotheses on the aetiology of pre-eclampsia, and provide targets for improved prediction, prevention and treatment

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-HEALTH-2011-single-stage
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

THE UNIVERSITY OF NOTTINGHAM
Address
University Park
NG7 2RD Nottingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 434 441
Administrative Contact
Alex Hammond (Ms.)

Participants (11)

REPUBLICAN STATE ENTERPRISE WITH ECONOMIC MANAGEMENT SCIENTIFIC CENTRE OF OBSTETRICS, GYNECOLOGY AND PERINATOLOGY OF MINISTRY OF HEALTH
Kazakhstan
EU contribution
€ 400 420
Address
Dostyk Ave 125
050020 Almaty
Activity type
Research Organisations
Administrative Contact
Gulnara Svyatova (Prof.)
RESPUBLIKA ISTISOSLASHTIRILGAN AKUSHERLIK VA GINEKOLOGIYA ILMIY-AMALIY TIBBIYOT MARKAZI
Uzbekistan
EU contribution
€ 107 200
Address
Mirzo Ulugbek 132-A
100 Tashkent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nodira Zakhidova (Dr.)
ISLENSK ERFDAGREINING EHF
Iceland
EU contribution
€ 1 424 550
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frosti Jonsson (Mr.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 209 761,20
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Berg (Ms.)
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
EU contribution
€ 71 010
Address
Hogskoleringen 1
7491 Trondheim
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rannveig Storeng Frøseth (Ms.)
FOLKEHELSEINSTITUTTET
Norway
EU contribution
€ 280 045
Address
Lovisenberggata 8
0456 Oslo
Activity type
Research Organisations
Administrative Contact
Ane Lunde (Ms.)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 482 450
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greg Dow (Mr.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 1 963 929,62
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
David Davison (Mr.)
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 172 983,60
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 114 048
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Hamilton (Mr.)
IMMUNOLOGIYA INSTITUTI O'ZBEKISTONRESPUBLIKASI FANLAR AKADEMIYASI
Uzbekistan
EU contribution
€ 300 810
Address
Ya Gulamov Street 74
100 Tashkent
Activity type
Research Organisations
Administrative Contact
Nodira Zakhidova (Dr.)