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Code-engineered new-to-nature microbial cell factories for novel and safety enhanced bio-production

Code-engineered new-to-nature microbial cell factories for novel and safety enhanced bio-production

Objective

The concept of METACODE is to preform genetic code engineering in microbial strains with parallel recruitment of novel bio-orthogonal chemistries for mass production of desired protein/peptide based products. In combination with computational and classical chemical synthetic approaches as well as chemo-informatics, enzyme guided evolution, synthetic metabolism, and directed evolution of microbial strains, artificial industrial microbial strains will be designed. This will enable the access to genetically robust and safe strains with added/novel functionalities and topologies from renewable resources. These strains will be characterized with alternative reading of the genetic code (genetic firewall) and with predetermined chemistries (metathesis), as well as necessary robustness for efficient industrial use.

Coordinator

TECHNISCHE UNIVERSITAT BERLIN

Address

Strasse Des 17 Juni 135
10623 Berlin

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 898 809

Administrative Contact

Silke Hönert (Ms.)

Participants (7)

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Isthmus

France

EU Contribution

€ 343 992

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 499 237

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 250 000

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 249 600

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 249 780

MOLECULAR NETWORKS GMBH COMPUTERCHEMIE

Germany

EU Contribution

€ 241 200

BIOFACTION KG

Austria

EU Contribution

€ 264 320

Project information

Grant agreement ID: 289572

Status

Closed project

  • Start date

    1 December 2011

  • End date

    30 November 2015

Funded under:

FP7-KBBE

  • Overall budget:

    € 3 892 149,80

  • EU contribution

    € 2 996 938

Coordinated by:

TECHNISCHE UNIVERSITAT BERLIN

Germany