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Novel biomimetic strategy for bone regeneration

Objective

The importance of developing novel approaches for bone repair is underscored by the heavy burden on health care costs and patient suffering caused by traumatic, osteoporotic and osteolytic metastatic bone lesions. To address these health challenges, we will develop optimally performing bioinspired biomaterials mimicking the natural physiological processes underlying bone repair. Our overall approach is to produce smart bioactive 3D scaffolds to fit within bone lesions, which we will then inject with functional, genetically-engineered self-solidifying elastin-like polymers with absolute-controlled molecular architecture and sequences containing specific domains for cell attachment, growth factors and calcium phosphate nanoparticles. The resulting bioactive, biodegradable scaffolds, biogels and regenerated bone will be analysed for biomaterial effects on bone growth, healing, foreign body reactions using cutting-edge in vitro assays, BioMEMS technology, in vivo animal models, non-invasive imaging and gene expression profiling for discovery of biomarkers associated with bone repair. Biomaterials will also be tested with biodynamic assays to assess strength, durability, toxicology, sterilisation reaction, eco-toxicology and risk assessment. Our multidisciplinary consortium with its extensive, state-of-the-art expertise consisting of private and public partners, cellular and molecular biologists, immunologists, physicists, bioengineers, and orthopaedic surgeons will tackle serious bone lesions with a comprehensive work plan to develop a prototype, evaluate it in vivo and in vitro, upscale its production and prepare the final material for clinical phase trials and commercialisation of the dual component product. Our ultimate aims are to ensure strong, healthy bone regeneration, reduce pain and suffering and to become a competitor in the biomaterials market of Europe.

Field of science

  • /engineering and technology/industrial biotechnology/biomaterials

Call for proposal

FP7-NMP-2010-LARGE-4
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITAT WIEN
Address
Universitatsring 1
1010 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 152 873
Administrative Contact
Helmut Schaschl (Dr.)

Participants (13)

Institut für Bioprozess- und Analysenmesstechnik e.V.
Germany
EU contribution
€ 559 739
Address
Rosenhof 1
37308 Heilbad Heiligenstadt
Activity type
Research Organisations
Administrative Contact
Klaus Liefeith (Prof.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 435 746
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaeffer (Ms.)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 581 075
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
Qserve Consultancy BV
Netherlands
EU contribution
€ 104 550
Address
Gordel Van Smaragd 23
1448 AE Purmerend
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Willibrord Driessen (Mr.)
BAXALTA INNOVATIONS GMBH
Austria
EU contribution
€ 103 830
Address
Industriestrasse 67
1221 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
John Barry (Dr.)
TETRA GESELLSCHAFT FUR SENSORIK ROBOTIK UND AUTOMATION MBH
Germany
EU contribution
€ 346 660
Address
Gewerbepark Am Wald 4
98693 Ilmenau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olaf Mollenhauer (Mr.)
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT
Switzerland
EU contribution
€ 728 233
Address
Rue Jaquet Droz 1
2000 Neuchatel
Activity type
Research Organisations
Administrative Contact
Martha Liley (Dr.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 769 033
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michelle Epstein (Dr.)
UNIVERSIDAD DE VALLADOLID
Spain
EU contribution
€ 449 040
Address
Plaza Santa Cruz 8 Palacio De Santa Cruz
47002 Valladolid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yolanda Calvo (Ms.)
UNIVERSITAT POLITECNICA DE CATALUNYA
Spain
EU contribution
€ 243 857
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cristina Costa (Ms.)
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 344 693
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christiane Hennecke (Ms.)
MOVERIM CONSULTING SPRL
Belgium
EU contribution
€ 148 800
Address
Square Ambiorix 32
1000 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Laura Vivani (Ms.)
PROMOSCIENCE SRL
Italy
EU contribution
€ 231 520
Address
Localita Padriciano 99
34012 Trieste
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Riccardo Brancaleon (Mr.)