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Identification of epigenetic markers underlying increased risk of T2D in South Asians

Objective

This project focuses on identification of epigenetic risk factors underlying the increased rates of type-2 diabetes (T2D) amongst South Asians in their home countries, migrants to Europe and other parts of the world. Known environmental and genetic factors explain only a small part of the increased risk of T2D among South Asians, who constitute the highest numbers of people with T2D worldwide.

We hypothesise that epigenetic modification contributes to the increased T2D risk amongst South Asians. We will carry out an epigenome-wide scan of DNA methylation in whole blood, among T2D cases and controls from non-migrant (living in India or Pakistan) and migrant (living in the UK) South Asians. Further testing of top-ranking markers will be carried out in South Asian T2D cases and controls from UK, India, Mauritius, Pakistan, Singapore and Sri Lanka. We will use results to investigate the mechanisms underlying the epigenetic modifications identified, to develop a predictive panel of lifestyle, environmental, genetic and epigenetic markers increasing susceptibility to incident T2D in South Asians, and to quantify the contribution of these risk factors to T2D amongst South Asians in diverse regional settings.

This research will improve understanding of epigenetic mechanisms underlying T2D, and may enable development of novel biomarkers and therapeutic strategies to reduce the burden of T2D amongst South Asians worldwide.

Field of science

  • /social sciences/sociology/social problems/migration
  • /medical and health sciences/clinical medicine/endocrinology/diabetes

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 717 908,60
Administrative Contact
Tatjana Palalic (Ms.)

Participants (12)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 988 054
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
DEVKI DEVI FOUNDATION SOCIETY
India
EU contribution
€ 360 024
Address
Press Enclave Road Saket 2
110017 New Delhi
Activity type
Research Organisations
Administrative Contact
Sujeet Jha (Dr.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 591 600
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pier Alberto Bertazzi (Prof.)
OULUN YLIOPISTO
Finland
EU contribution
€ 89 378,40
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arto Eljander (Mr.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 102 012
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Berg (Ms.)
BAKER HEART AND DIABETES INSTITUTE
Australia
EU contribution
€ 62 928
Address
Commercial Road 75 Victoria
3104 Melbourne
Activity type
Research Organisations
Administrative Contact
Heather Gallichio (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 64 794
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Danish Saleheen (Dr.)
NATIONAL UNIVERSITY OF SINGAPORE PUBLIC COMPANY LIMITED BY GUARANTEE
Singapore
EU contribution
€ 7 353
Address
Lower Kent Ridge Road 21
119077 Singapore
Activity type
Higher or Secondary Education Establishments
Administrative Contact
E Shyong Tai (Prof.)
UNIVERSITY OF KELANIYA
Sri Lanka
EU contribution
€ 6 300
Address
Dalugama
Kelaniya
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ar Wickremasinghe (Prof.)
CELLCENTRIC LIMITED
United Kingdom
EU contribution
€ 2 400
Address
Chesterford Research Park, Little Chesterford
CB10 1XL Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tim Fell (Dr.)
National Center for Global Health and Medicine
Japan
Address
Toyama 1-21-1
1628655 Tokyo
Activity type
Research Organisations
Administrative Contact
Terumasa Matsuoka (Dr.)
UNIVERSITY OF MAURITIUS
Mauritius
EU contribution
€ 6 300
Address
Reduit
Reduit
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chaya Bholah (Ms.)