Skip to main content

Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population

Objective

Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night disturb the circadian clocks and severely disrupt endocrine and metabolic processes, contributing to an increased risk of type 2 diabetes/obesity. Especially shift workers constituting 20% of the European working population are affected by this prob-lem. Until now only few studies investigating circadian rhythm disturbances in the context of type 2 diabetes/obesity have been conducted in man. Within EuRhythDia a consortium of leading scientists supported by research-intensive SMEs aims to close this gap. The objective of the project is to achieve breakthroughs in the understanding of the causality between inner clock rhythm disturbances and the development of type 2 diabetes/obesity, and to verify whether re-setting the circadian clock through lifestyle interventions (exercise, diet, light exposure and melatonin intake) alters cardiometabolic risk to a clinically relevant degree. The project is based on shift workers as a model and combines genetic, epigenetic, proteomic, metabolomic, physiological, and clinical approaches. The consortium has direct access to well characterised human data incl. individuals predisposed to type 2 diabetes via LUPS co-hort. Additional small interventional and validation cohorts of shift workers and high risk juveniles will be recruited, and supportive animal studies will be conducted. Through the de-velopment of novel diagnostic assays enabling identification of patients at risk and elaboration of targeted prevention guidelines focusing on shift workers and juveniles, EuRhythDia will contribute to a positive impact on European citizens` health.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Address
Martinistrasse 52
20251 Hamburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 575 228,80
Administrative Contact
Rainer H. Böger (Prof.)

Participants (16)

UNIVERSITAETSKLINIKUM AACHEN
Germany
EU contribution
€ 222 879,60
Address
Pauwelsstrasse 30
52074 Aachen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Volker Legewie (Mr.)
European ScreeningPort GmbH

Participation ended

Germany
EU contribution
€ 374 685,26
Address
Schnackenburgallee
22525 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mira Grättinger (Dr.)
GENEDATA AG
Switzerland
EU contribution
€ 188 332,91
Address
Margarethenstrasse 38
4053 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Timo Wittenberger (Dr.)
GERMEDIQ FORSCHUNGS-UND ENTWICKLUNGSGESELLSCHAFT MBH

Participation ended

Germany
Address
Konig Heinrich Weg 48
22459 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gerhild Böger (Dr.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 179 704,40
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sanna Leppämäki (Ms.)
FEDERATION INTERNATIONALE DU DIABETE REGION EUROPE AISBL
Belgium
EU contribution
€ 111 683
Address
Chaussee De La Hulpe 166 Bloc C
1170 Bruxelles
Activity type
Other
Administrative Contact
Sophie Peresson (Mrs.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 705 100
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Hamilton (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 152 501,60
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Ouwerkerk (Ms.)
UNIVERSITE DE LILLE II - DROIT ET SANTE
France
EU contribution
€ 790 518,99
Address
Rue Paul Duez 42
59800 Lille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie Gompel (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health

Participation ended

United Kingdom
EU contribution
€ 198 793
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
OUTSIDE IN (CAMBRIDGE) LTD
United Kingdom
EU contribution
€ 58 168
Address
The Links Trafalgar Way Bar Hill 3
CB23 8UD Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jonathan Cridland (Mr.)
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
EU contribution
€ 124 800
Address
Langenbeckstrasse 1
55131 Mainz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Uta Veith (Dr.)
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
EU contribution
€ 707 000,04
Address
Via Cracovia 50
00133 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Pallone (Prof.)
GEMEINNUTZIGE SALZBURGER LANDESKLINIKEN BETRIEBSGESELLSCHAFT
Austria
EU contribution
€ 262 200
Address
Mullner Hauptstrasse 48
5020 Salzburg
Activity type
Other
Administrative Contact
Josef Niebauer (Prof.)
UNIVERSITY OF SURREY
United Kingdom
EU contribution
€ 252 133,50
Address
Stag Hill
GU2 7XH Guildford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Sega-Buhalis (Ms.)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 94 160,35
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Michael Prestele (Mr.)