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"""RNPnet"" - RNP structure, function and mechanism of action"

Objective

RNA molecules are at the heart of life. It is now commonly admitted that nearly all the human genome is transcribed, and a wealth of new coding and non-coding RNAs have been discovered. Importantly, modern RNAs are never naked, but always exist in complex with proteins to form RNPs (Ribonucleoproteins). In the case of non-coding RNAs, these proteins are usually stably associated with the RNA and help to perform their function. In contrast, RNA binding proteins are usually transiently bound to coding RNAs, and control various aspects of their metabolism. For the next generation of scientists, a great challenge will be to understand the function and the mechanisms of action of the myriads of RNPs.
The goal of this ITN (“RNPnet”) is first to bring together existing labs from different discipline, to join forces and tackle key questions in the field, and second, to produce highly-trained young researchers that will be sensitized to RNA and possess a multidisciplinary approach to research. The multiple expertises present in the fifteen labs of this network will be used in a highly cooperative and integrated manner. The research training will focus on studying RNPs involved in mRNA surveillance, splicing and editing. In addition, a total of fifteen meetings including two summer schools and several workshops are planed to strengthen education and interaction among participants of RNPnet.
Finally, another important aspect of RNPnet is the presence of two industrial partners. Their aim is to use the enormous potential of RNA biology in therapeutic applications, either by modifying RNAs and using it as a drug, or by targeting specific RNA binding proteins with small molecules. We foresee that the presence of industrial partners will be highly beneficial for the students, and that, by exposing them to both the academic and industrial world, we will both facilitate communication between these worlds and provide to the young trainees a large panorama of their possible career.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/rna
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-PEOPLE-2011-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)
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Coordinator

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Address
Raemistrasse 101
8092 Zuerich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 584 344,29
Administrative Contact
Frédéric Allain (Prof.)

Participants (14)

SPLICOS SAS

Participation ended

France
Address
Route De Mende 1919
34293 Montpellier
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Didier Scherrer (Dr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 721 678,20
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Phil Irving (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 298 095,61
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Jocelyn Mere (Dr.)
ECOLE NORMALE SUPERIEURE
France
EU contribution
€ 276 095,61
Address
45, Rue D'ulm
75230 Paris Cedex 05
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Cormier (Ms.)
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal
EU contribution
€ 209 892,11
Address
Avenida Prof Egas Moniz
1649 028 Lisboa
Activity type
Research Organisations
Administrative Contact
Margarida Pinto Gago (Dr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 473 052,79
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other
Administrative Contact
Ulrike Jendis
UNIVERSIDAD POMPEU FABRA
Spain
EU contribution
€ 228 204,90
Address
Placa De La Merce, 10-12
08002 Barcelona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Martin Garcia (Ms.)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 244 780,80
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hans Widmer (Dr.)
UNIVERSITAET INNSBRUCK
Austria
EU contribution
€ 240 045,30
Address
Innrain 52
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ronald Micura Ronald (Prof.)
Biologicke centrum AV CR, v. v. i.
Czechia
EU contribution
€ 210 680,81
Address
Branisovska 31
370 05 Ceske Budejovice
Activity type
Research Organisations
Administrative Contact
Julius Lukeš (Prof.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 261 200,51
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Elizabeth Cutler (Ms.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 244 780,80
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mihaela Zavolan (Dr.)
ABIVAX
France
EU contribution
€ 254 095,61
Address
5 Rue De La Baume
75008 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Didier Scherrer (Dr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Participation ended

Germany
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Janine Heyder (Ms.)