Objective Motor behaviour requires the meaningful integration of a multitude of sensory information. The basal ganglia are essential for such sensory-motor processing and underlie motor planning, performance, and learning. The striatum is the input layer of the basal ganglia, acting as a “hub” that receives synaptic inputs from different brain regions, interacting primarily with the GABAergic striatal microcircuit. Sensory excitatory inputs to striatum arise from the thalamus and neocortex, targeting striatal projection neurons and interneurons.Previous work in basal ganglia focused mainly on their role in motor and reward related functions, but the functional role of striatum in sensory processing is largely unknown. In this study I will elucidate the principles of sensory processing performed at the striatal microcircuit. In particular, I aim to answer these fundamental questions:- How do striatal neurons integrate sensory input? How is sensory input from different sensory modalities integrated in the striatum? How are ipsi- and contralateral inputs integrated?- What are the respective roles of cortical and thalamic sensory inputs in striatal function?- How is the intra-striatal microcircuitry organized to support sensory integration?To address these questions I will use a combination of electrophysiological, optical, and anatomical methods, including:- In vivo whole-cell recordings from striatal neurons during visual and tactile stimulation.- Multi-neuron whole-cell recordings in corticostriatal and thalamostriatal slices.- Optical manipulation of identified neuronal subpopulations in slice and in vivo.The proposed study will provide a new understanding of sensory processing at the level of basal ganglia and may provide insights regarding basal ganglia dysfunction. Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-LS5 - ERC Starting Grant - Neurosciences and neural disorders Call for proposal ERC-2011-StG_20101109 See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Host institution KAROLINSKA INSTITUTET EU contribution € 1 494 445,00 Address Nobels Vag 5 17177 Stockholm Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact åsa Garmager (Ms.) Principal investigator Gilad Daniel Silberberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all KAROLINSKA INSTITUTET Sweden EU contribution € 1 494 445,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact åsa Garmager (Ms.) Principal investigator Gilad Daniel Silberberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data