CORDIS
EU research results

CORDIS

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Genetic and physiological basis of thinness

Project information

Grant agreement ID: 282374

Status

Closed project

  • Start date

    1 January 2012

  • End date

    31 December 2016

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Hosted by:

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

Objective

"The rising prevalence of obesity and associated co-morbidities such as Type 2 diabetes, cardiovascular disease and certain cancers represents a major threat to public health in Europe and worldwide. It can be argued that modern westernized environments are obesity promoting due to unprecedented economic growth, decreased incidence of infectious disease, nearly unlimited food supply, a wide availability of high fat, highly palatable pre-prepared foods, large portion sizes and technological advances leading to a more sedentary lifestyles. The influence on the whole population of environmental factors is undoubtedly powerful, but one remarkable feature of the obesity epidemic is the persistence of enormous individual variation in body weight throughout the population. Individual differences seem to be increasing in both children and adults, with the lean staying lean while the obese become more obese, which indicates that individuals interact differently with the ‘obesogenic’ environment. There is strong evidence that within a population the variance in weight is largely genetically determined. Given that common obesity results from an imbalance between energy intake and expenditure, it is highly likely that this interaction occurs partly through individual variation in appetite and eating behaviours. To date virtually all research based at finding genes related to obesity has focussed on the upper end of the body mass index (BMI) distribution. As part of this proposal I propose a complementary gene finding strategy that focuses on the lowest end of the BMI distribution in order to find genes that confer resistance to obesity in an obesogenic society. The identification of such genes may explain why some individuals do not become obese despite environmental provocation. Insights into the biology of thinness and obesity resistance could lead to rational preventative and therapeutic strategies for obesity."

Principal Investigator

Ismaa Sadaf Farooqi (Dr.)

Host institution

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

Address

Trinity Lane The Old Schools
Cb2 1tn Cambridge

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 200 000

Principal Investigator

Ismaa Sadaf Farooqi (Dr.)

Administrative Contact

Renata Schaeffer (Ms.)

Beneficiaries (2)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 1 200 000

GENOME RESEARCH LIMITED

United Kingdom

EU Contribution

€ 300 000

Project information

Grant agreement ID: 282374

Status

Closed project

  • Start date

    1 January 2012

  • End date

    31 December 2016

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Hosted by:

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

United Kingdom