Skip to main content

Patient-specific predictions for bone treatments

Objective

CAD-BONE addresses a multidisciplinary research that will transform current technology by radically improving the development of patient-specific computer models for the modelling of bone remodelling/healing to predict short and long-term bone response after surgical interventions. Specifically, CAD-BONE will combine image processing, musculoskeletal modelling tools, finite element analyses and bone remodelling/healing algorithms to provide an understanding of the individual functional outcome of patient treatments from standard clinical radiographs. Although already developed and broadly in use, these computer technologies and methods are yet to be combined and integrated to create a computer tool with a predictive purpose. To successfully achieve this objective different scientific and technological challenges will be faced. Firstly, the automatic construction of patient-specific finite element models of specific bones (including geometries, loads and boundary conditions). Secondly, The improvement of current bone remodelling/healing models, which are very slow, labour-intesive and costly processes, in order to achieve accurate near real-time results; to do so, different strategies based on model reduction techniques will be explored). And, finally, the quantitative validation of these patient-specific models. Such a validation will require a quantitative comparison between real bone density distributions obtained by computer tomography (CT) and those predicted from computer simulations.
Therefore, we expect that CAD-BONE can lead to a preliminary tool for the prediction of bone morphological changes resulting from changes in mechanical loading conditions.

Call for proposal

FP7-PEOPLE-2011-IAPP
See other projects for this call

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSIDAD DE ZARAGOZA
Address
Calle Pedro Cerbuna 12
50009 Zaragoza
Spain

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jose Manuel Garcia-Aznar (Dr.)
EU contribution
€ 187 601

Participants (2)

MATERIALISE NV
Belgium
EU contribution
€ 224 587
Address
Technologielaan 15
3001 Heverlee

See on map

Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roel Wirix-Speetjens (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 170 602
Address
Oude Markt 13
3000 Leuven

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sofie Heroes (Ms.)