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Rational Bioactive Materials Design for Tissue Regeneration

Objective

The development of functional materials for tissue regeneration is today mostly based on perceived and limited design criteria often using a single point approach with lengthy animal trials. The outcome after in-vitro and in-vivo evaluation is often disappointing resulting in a tedious iteration process. The main objective of this project is to achieve radical innovations in state-of-the-art biomaterials and to design highly performing bioinspired materials learning from natural processes. By this outcome driven project comprising first class academic and industrial participants the project will create scientific and technical excellence and through links with these SMEs will strengthen the technological capacity and their ability to operate competitively on an international market. BIODESIGN will (i) perform a careful retrospective-analysis of previous outcomes from clinical studies performed with humans through animal modelling in a reverse engineering approach applied to an in-vitro to the molecular design level, (ii) develop new strategies for a more rational design of ECM mimetic materials serving both as gels and load carrying scaffolds, (iii) link novel designs to adequate and more predictive in-vitro methods allowing significant reduction in development time and use of animals and (iv) evaluate these concepts for musculoskeletal and cardiac regeneration. By the development of safe, ethically and regulatory acceptable, and clinically applicable materials this project will promote harmonization while at the same time creating awareness in society of the benefits of these innovations as one of the key points is to improve health and quality of life of the patients. BIODESIGN will stimulate technological innovation, utilization of research results, transfer of knowledge and technologies and creation of technology based business in Europe. It will also support the development of world-class human resources, making Europe a more attractive to top researchers.

Call for proposal

FP7-NMP-2010-LARGE-4
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Coordinator

UPPSALA UNIVERSITET
Address
Von Kraemers Alle 4
751 05 Uppsala
Sweden

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulf Westerlund (Mr.)
EU contribution
€ 2 126 515,53

Participants (20)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 825 471
Address
Raemistrasse 101
8092 Zuerich

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ralph Müller (Prof.)
AO-FORSCHUNGSINSTITUT DAVOS
Switzerland
EU contribution
€ 573 042
Address
Clavadelerstrasse 8
7270 Davos Platz

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Activity type
Research Organisations
Administrative Contact
Mauro Alini (Prof.)
LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG
Austria
EU contribution
€ 445 260
Address
Nussdorfer Strasse 64/6
1090 Wien

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Activity type
Research Organisations
Administrative Contact
Juan Cabello (Mr.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 435 467
Address
Martinistrasse 52
20251 Hamburg

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Neumann (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 741 591,62
Address
Gower Street
WC1E 6BT London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
EU contribution
€ 594 796
Address
Senate Building Technion City
32000 Haifa

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lavan Jack (Mr.)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 489 857
Address
University Park
NG7 2RD Nottingham

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
UNIVERSITY OF KEELE ROYAL CHARTER
United Kingdom
EU contribution
€ 538 211
Address
Keele University Finance Dpt
ST5 5BG Keele

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hooper (Dr.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 591 325,47
Address
Highfield
SO17 1BJ Southampton

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yan Qiao (Ms.)
STRYKER TRAUMA GMBH
Germany
EU contribution
€ 243 805
Address
Prof Kuntscher Strasse 1-5
24232 Schonkirchen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philip Procter (Dr.)
REGENTIS BIOMATERIALS LTD
Israel
EU contribution
€ 757 208,75
Address
Ha Ilan Street 2 Northern Industrial Zone
30600 Or Akiva

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alastair John Clemow (Dr.)
DANDO WEISS & COLUCCI LIMITED

Participation ended

United Kingdom
EU contribution
€ 50 691,95
Address
Lower Bristol Road Minerva House
BA2 9ER Bath

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jonathan Dando (Dr.)
TERMIRA AB

Participation ended

Sweden
EU contribution
€ 19 489,25
Address
Malmgardsvagen 32A
116 38 Stockholm

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
John Lennart Soderberg (Mr.)
LOCATE THERAPEUTICS LIMITED
United Kingdom
EU contribution
€ 492 344
Address
Medicity Thane Road Beeston
NG90 6BH Nottingham

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robin Quirk (Dr.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 463 274
Address
Batiment Ce 3316 Station 1
1015 Lausanne

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Fernandes Coelho (Ms.)
UNIVERSITY OF NOTTINGHAM IN MALAYSIA
Malaysia
EU contribution
€ 353 335
Address
Jalan Raja Chulan (Bousteam Holdings) 69
50200 Kuala Lumpur

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
David Crowley (Mr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 517 790
Address
Strand
WC2R 2LS London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labett (Mr.)
TRAUMA CARE CONSULT TRAUMATOLOGISCHE FORSCHUNG GEMEINNUTZIGE GMBH
Austria
EU contribution
€ 222 957
Address
Gonzagagasse 11/25
1010 Wien

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juan Cabello
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 380 426,38
Address
Oxford Road
M13 9PL Manchester

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claire Faichnie (Ms.)
LALIT AB
Sweden
EU contribution
€ 104 108,05
Address
Asogatan 106
118 29 Stockholm

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Malin Nilsson (Dr.)