Obiettivo Currently, no specific and causative therapy for the treatment of inflammatory skin diseases, e.g. atopic dermatitis and psoriasis, is available. To create new treatment options for these diseases, the applicants plan a strategic partnership by the mutual exchange of knowledge. Both the industrial partner, IPF PharmaCeuticals (Hannover, Germany), and the academic partner, Centro de Investigaciones Biologicas (Madrid, Spain), will contribute to the know-how transfer in the field of applied protein research for the examination of newly discovered serine proteinases and their inhibitors. A multi-domain serine proteinase inhibitor (LEKTI) was identified and was shown to play a significant role in the development of skin diseases. Based on these findings, the proposed research aims to examine the (patho-)physiological role of relevant serine proteinases and their pertinent inhibitors for the discovery of new drugs against skin diseases. The cooperation between the German company and the institution from the Spanish Council of Scientific Research (CSIC) will result in a long-lasting strategic partnership taking advantage of complementary know-how of each organization and of the different scientific and economic networks in these two countries of the EC.The applicants have a long-standing experience in the organization of scientific research collaborations, workshops, execution of scientific grants, publications, patent issues and in the exploition of intellectual property rights. This research co-operation plans (i) to identify and produce serine proteinases and their inhibitors related to atopic dermatitis and psoriasis, (ii) to elucidate their three-dimensional structure, (iii) on the basis of this knowledge to design optimized inhibitors, and (iv) to test the pharmacological potential of the inhibitors in animal models for skin diseases. Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Parole chiave Analysis Atopic Dermatitis Inhibitor Proteinase Psoriasis Structure Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-1.3.2 - Marie Curie Host Fellowships - Transfer of knowledge (TOK) - Industry-Academia Strategic Partnership Scheme Invito a presentare proposte FP6-2002-MOBILITY-3 Vedi altri progetti per questo bando Meccanismo di finanziamento TOK - Marie Curie actions-Transfer of Knowledge Coordinatore IPF PHARMACEUTICALS Contributo UE Nessun dato Indirizzo Feodor Lynen Str. 31 HANNOVER Germania Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spagna Contributo UE Nessun dato Indirizzo Serrano 117 MADRID Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato