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Psychiatric Diagnostic and Prevention Consortium

Objective

PsychDPC contains leading European centres in genetics and psychiatry, richly endowed with expertise in both clinical and basic research. The partners bring together state-of-the-art technical facilities, high academic standards as well as established training activities, which will be utilized in concert to maximise the outcome of the project. The primary aim of PsychDPC is to translate data emerging from large-scale research efforts in genetic and genomic epidemiology of schizophrenia, conducted on large sets of well-characterized volunteer patients, into information of relevance to current practice and future clinical advances. PsychDPC will do this through effective integration of data between the partners. A range of complementary approaches will be applied with an initial focus on: 1) Discovery of novel genetic susceptibility variants from genome wide SNP association data through expanding the large sample sets accessible to partners and by imputing available sequence data into the large genotyped datasets, 2) study of the phenotypic stamp conferred by copy number variations (CNVs) and genes harbouring non-synonymous point mutations conferring high and moderate risk of schizophrenia, 3) powerful novel genetic approaches to genetic discovery including long range phasing combined with deep sequencing and 4) analysis of the relationship of uncovered variants conferring risk of schizophrenia with clinical, neurpsychological and brain structure phenotypes. The consortium has unique, very large samples from schizophrenia patients and the aim is to re-phenotype subjects carrying variants conferring high-risk to identify their specific cognitive and behavioural features. Combined with a refinement of familial risk assessment, using comprehensive national registry databases, we will utilise our findings to develop diagnostic tools, tools for early intervention and genetic counselling.
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Coordinator

ISLENSK ERFDAGREINING EHF

Address

Sturlugotu 8
101 Reykjavik

Iceland

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 899 817

Administrative Contact

Frosti Jonsson (Mr.)

Participants (5)

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KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 157 491

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 292 129

UNIVERSITETET I OSLO

Norway

EU Contribution

€ 235 370

MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG

Germany

EU Contribution

€ 194 452

Project information

Grant agreement ID: 286213

Status

Closed project

  • Start date

    1 January 2012

  • End date

    31 July 2016

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 1 779 259

  • EU contribution

    € 1 779 259

Coordinated by:

ISLENSK ERFDAGREINING EHF

Iceland