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Products from methanol by synthetic cell factories

Objective

There is a high societal need for a sustainable production of key chemistry, food and health care compounds. Microbial cell factories are logical production systems, but up to now they use sugars and other food derived raw materials as substrates. Sugars originating from plants demand cultivable land which is more and more needed for human nutrition. Methanol - with a worldwide production capacity of more than 46 million tons per year - is regarded as an alternative highly attractive raw material in microbial fermentation for the manufacturing of special, fine, bulk, and fuel chemicals. This is especially true for the EU market, where industrial biotechnology still is hampered by strict use and price regulations as well as import limitations for agricultural commodities, such as corn or sugar. The supply of methanol can base upon both fossil and renewable resources, rendering it a highly flexible and sustainable raw material. Our vision is a viable methanol-based European bio-economy, which we will promote by for the first time applying synthetic biology principles for cell factory development in order to harness methanol as a general feedstock for the manufacturing of special and fine chemicals. In nature, methylotrophic microorganisms can utilize methanol as their sole source of carbon and energy. The project PROMYSE will deliver an alternative route to sought-after chemicals, with a major focus on terpenoids. PROMYSE combines two frontline research topics: orthogonal modularization of methylotrophy within a Synthetic Biology concept and employing methanol as a feedstock for biotechnological production. Through the transfer of methylotrophy modules, Synthetic Biology will pave the way to capitalize on the metabolic versatility and engineered production pathways of genetically well tractable microorganisms, such as E. coli, B. subtilis and C. glutamicum for biotransformation from methanol.

Call for proposal

FP7-KBBE-2011-5
See other projects for this call

Coordinator

STIFTELSEN SINTEF
Address
Strindveien 4
7034 Trondheim
Norway
Activity type
Research Organisations
EU contribution
€ 565 313
Administrative Contact
Tove Lillian Hønstad (Ms.)

Participants (9)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 399 423
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Julia Vorholt (Prof.)
UNIVERSITAET BIELEFELD
Germany
EU contribution
€ 388 500
Address
Universitaetsstrasse 25
33615 Bielefeld
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Iris Litty
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 390 349
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Poutsma (Mr.)
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE
France
EU contribution
€ 390 521
Address
Avenue De Rangueil 135
31077 Toulouse
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nicolas Combebiac (Mr.)
DECHEMA-FORSCHUNGSINSTITUT STIFTUNG
Germany
EU contribution
€ 390 060
Address
Theodor Heuss Allee 25
60486 Frankfurt
Activity type
Research Organisations
Administrative Contact
Jens Schrader (Dr.)
INSILICO BIOTECHNOLOGY AG
Germany
EU contribution
€ 275 700
Address
Meitnerstrasse 9
70563 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Klaus Mauch (Mr.)
PROMAR AS
Norway
EU contribution
€ 112 908
Address
Rolfsbuktveien 17
1364 Fornebu
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Audun Goksøyr (Mr.)
BASF SE
Germany
EU contribution
€ 55 985
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hermann Feise (Dr.)
DECHEMA GESELLSCHAFT FUER CHEMISCHE TECHNIK UND BIOTECHNOLOGIE E.V.
Germany
Address
Theodor Heuss Allee 25
60486 Frankfurt
Activity type
Research Organisations
Administrative Contact
Jens Schrader (Dr.)