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High-throughput peptidomics and transcriptomics of animal venoms for discovery of novel therapeutic peptides and innovative drug development

Objective

Animal venoms are complex cocktails of peptides that have enormous potential as novel therapeutic leads. Replicating in vitro the diversity of venoms by generating large synthetic combinatorial peptide libraries will solve the challenge of working with limited amounts of natural products and permit high-throughput investigation of their pharmacology. A new investigation paradigm associating transcriptomics and proteomics is the only way to achieve this goal and to address the complexity of this unexplored 40,000,000 peptide resource. The vision of the VENOMICS project is to develop, integrate and implement cutting-edge and innovative technologies in a high-throughput approach to investigate the enormous structural and pharmacological diversity of venom peptides. We will use the largest venom and venom gland collection in the world to generate a comprehensive sequence database of bioactive peptides, and produce a 10,000 reticulated peptide bank to be used in drug discovery efforts and development of novel therapeutics. A 1000-fold improvement in throughput over the current situation (1 to 2 candidates generated per year) is reasonably foreseen.
Implementation of the project will require both improvements and the integration of exisiting technologies in a high-throughput workflow comprising venom and tissue sourcing, mass spectrometry-based automated de novo peptide sequencing, transcriptomics of venom gland-derived RNA or cDNA/EST libraries, bioinformatics, implementation of a sequence database, and highly parallel synthetic or recombinant production including peptide refolding. The last step will be the validation of the approach in functional assays targeting specific pathologies. VENOMICS is a high-impact project with societal (new drugs against life threatening diseases), scientific and technological (filling the drug discovery pipeline), political (European leadership in the field) and economic (new opportunities for the biologics market) benefits.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Address
Rue Leblanc 25
75015 Paris 15
France
Activity type
Research Organisations
EU contribution
€ 1 319 885,36
Administrative Contact
Nicolas Gilles (Dr.)

Participants (9)

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

Participation ended

France
EU contribution
€ 1 280,38
Address
Boulevard Charles Livon, Jardin Du Pharo 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Damon (Ms.)
VENOMETECH SAS

Participation ended

France
EU contribution
€ 373 912,96
Address
Route Des Dolines 473 Villa 3
06560 Valbonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pierre Escoubas (Dr.)
SISTEMAS GENOMICOS SL
Spain
EU contribution
€ 1 185 049,60
Address
Ronda G Marconi - Parque Tecnologico De Valencia 6
46980 Paterna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rebeca Miñambres Herráiz (Dr.)
NZYTECH LDA
Portugal
EU contribution
€ 737 800
Address
Estrada Do Paco Do Lumiar Campus Do Lumiar Edificio E - R/c
1649 038 Lisboa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carlos Fontes (Prof.)
ABSISKEY CP
France
EU contribution
€ 159 000
Address
Rue Colonel Dumont 26
38000 Grenoble
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olivier De Bardonneche (Mr.)
ZEALAND PHARMACEUTICALS AS
Denmark
EU contribution
€ 344 400
Address
Smedeland 36
2600 Glostrup
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cristian Grøndahl (Dr.)
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 836 887,35
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Céline Damon (Ms.)
UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 1 040 571
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Edwin De Pauw (Prof.)
KATHOLIEKE UNIVERSITEIT LEUVEN

Participation ended

Belgium
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Myriam Witvrouw (Dr.)