Skip to main content

High-throughput peptidomics and transcriptomics of animal venoms for discovery of novel therapeutic peptides and innovative drug development

Cel

Animal venoms are complex cocktails of peptides that have enormous potential as novel therapeutic leads. Replicating in vitro the diversity of venoms by generating large synthetic combinatorial peptide libraries will solve the challenge of working with limited amounts of natural products and permit high-throughput investigation of their pharmacology. A new investigation paradigm associating transcriptomics and proteomics is the only way to achieve this goal and to address the complexity of this unexplored 40,000,000 peptide resource. The vision of the VENOMICS project is to develop, integrate and implement cutting-edge and innovative technologies in a high-throughput approach to investigate the enormous structural and pharmacological diversity of venom peptides. We will use the largest venom and venom gland collection in the world to generate a comprehensive sequence database of bioactive peptides, and produce a 10,000 reticulated peptide bank to be used in drug discovery efforts and development of novel therapeutics. A 1000-fold improvement in throughput over the current situation (1 to 2 candidates generated per year) is reasonably foreseen.
Implementation of the project will require both improvements and the integration of exisiting technologies in a high-throughput workflow comprising venom and tissue sourcing, mass spectrometry-based automated de novo peptide sequencing, transcriptomics of venom gland-derived RNA or cDNA/EST libraries, bioinformatics, implementation of a sequence database, and highly parallel synthetic or recombinant production including peptide refolding. The last step will be the validation of the approach in functional assays targeting specific pathologies. VENOMICS is a high-impact project with societal (new drugs against life threatening diseases), scientific and technological (filling the drug discovery pipeline), political (European leadership in the field) and economic (new opportunities for the biologics market) benefits.

Zaproszenie do składania wniosków

FP7-HEALTH-2011-two-stage
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Adres
Rue Leblanc 25
75015 Paris 15
Francja

Zobacz na mapie

Rodzaj działalności
Research Organisations
Kontakt administracyjny
Nicolas Gilles (Dr.)
Wkład UE
€ 1 319 885,36

Uczestnicy (9)

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

Zakończenie uczestnictwa

Francja
Wkład UE
€ 1 280,38
Adres
Boulevard Charles Livon, Jardin Du Pharo 58
13284 Marseille

Zobacz na mapie

Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Celine Damon (Ms.)
VENOMETECH SAS

Zakończenie uczestnictwa

Francja
Wkład UE
€ 373 912,96
Adres
Route Des Dolines 473 Villa 3
06560 Valbonne

Zobacz na mapie

Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Pierre Escoubas (Dr.)
SISTEMAS GENOMICOS SL
Hiszpania
Wkład UE
€ 1 185 049,60
Adres
Ronda G Marconi - Parque Tecnologico De Valencia 6
46980 Paterna

Zobacz na mapie

Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Rebeca Miñambres Herráiz (Dr.)
NZYTECH LDA
Portugalia
Wkład UE
€ 737 800
Adres
Estrada Do Paco Do Lumiar Campus Do Lumiar Edificio E - R/c
1649 038 Lisboa

Zobacz na mapie

Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Carlos Fontes (Prof.)
ABSISKEY CP
Francja
Wkład UE
€ 159 000
Adres
Rue Colonel Dumont 26
38000 Grenoble

Zobacz na mapie

Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Olivier De Bardonneche (Mr.)
ZEALAND PHARMACEUTICALS AS
Dania
Wkład UE
€ 344 400
Adres
Smedeland 36
2600 Glostrup

Zobacz na mapie

Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Cristian Grøndahl (Dr.)
UNIVERSITE D'AIX MARSEILLE
Francja
Wkład UE
€ 836 887,35
Adres
Boulevard Charles Livon 58 Le Pharo
13284 Marseille

Zobacz na mapie

Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Céline Damon (Ms.)
UNIVERSITE DE LIEGE
Belgia
Wkład UE
€ 1 040 571
Adres
Place Du 20 Aout 7
4000 Liege

Zobacz na mapie

Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Edwin De Pauw (Prof.)
KATHOLIEKE UNIVERSITEIT LEUVEN

Zakończenie uczestnictwa

Belgia
Adres
Oude Markt 13
3000 Leuven

Zobacz na mapie

Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Myriam Witvrouw (Dr.)