Skip to main content

Novel approaches for prevention and degeneration of pathogenic bacteria biofilms formed on medical devices e.g. catheters

Objetivo

Biofilms are bacterial communities encased in a self-produced hydrated polymeric matrix. An important characteristic of microbial biofilms is their innate resistance to the immune system and susceptibility to antibiotics. This resistance has made microbial biofilms a common cause of medical infections, and difficult-to-treat infections caused by colonized foreign bodies.
The NOVO project aims at developing novel approaches to prevent and/or degrade biofilms on catheters elongating their usage in humans up to 10 days.
Two complementary approaches for biofilm prophylaxis will be developed:
A. Ultrasonic coating of Inorganic antibiofouling agents (process developed by partner BIU) based on a single step sonochemical process to: a) Produce metal fluorides or metal oxides (e.g. MgF2, ZnO) nanoparticles (NPs) and simultaneously b) Impregnate them as antibacterial factors on the catheters. c) Co-coating with bio-inert polymer layers (containing highly hydrophilic antifouling polyethylene glycol, zwitterionic moieties or sugar-groups) grafted onto NPs of adjusted size to the size of MgF2/ZnO NPs or directly onto MgF2/ZnO NPs; to form a hydrogel layer for the protection of the MgF2/ZnO antibiofouling activity.
B. Bio/organic antibiofouling activation: 1) Novel coating for catheters based on radical catalyzed polymers to yield anti-bacterial activity. An enzymatic reaction will be applied on the phenolic compounds to generate phenolic radicals to be further polymerized on the catheter surface as an antibiofilm agent. 2) Develop and engineer Cellobiose Dehydrogenases (CDH) that actively oxidizes and degrades biofilms polysaccharides concomitantly producing stoichiometrically H2O2 as antibacterial agent. The enzymes will be coated on the catheters via a lubricant or by the Ultrasonic (US) process after their immobilization. Some novel CDH representatives already show very low activity on glucose which should be removed by further genetic engineering.

Convocatoria de propuestas

FP7-HEALTH-2011-two-stage
Consulte otros proyectos de esta convocatoria

Coordinador

UNIVERSITAET FUER BODENKULTUR WIEN
Dirección
Gregor Mendel Strasse 33
1180 Wien
Austria

Ver en el mapa

Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Georg Guebitz (Prof.)
Aportación de la UE
€ 405 402,38

Participantes (11)

BAR ILAN UNIVERSITY
Israel
Aportación de la UE
€ 399 740
Dirección
Bar Ilan University Campus
52900 Ramat Gan

Ver en el mapa

Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Estelle Waise (Ms.)
UNIVERSITAT POLITECNICA DE CATALUNYA
España
Aportación de la UE
€ 268 245
Dirección
Calle Jordi Girona 31
08034 Barcelona

Ver en el mapa

Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Cristina Costa (Ms.)
UNIVERSITAET DUISBURG-ESSEN
Alemania
Aportación de la UE
€ 276 000
Dirección
Universitatsstrasse 2
45141 Essen

Ver en el mapa

Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Kirsten Gercek (Ms.)
MULTIPROFILE HOSPITAL FOR ACTIVE TREATMENT AND EMERGENCY MEDECINE PIROGOV
Bulgaria
Aportación de la UE
€ 123 960
Dirección
Totleben Blvd 21
1606 Sofia

Ver en el mapa

Tipo de actividad
Research Organisations
Contacto administrativo
Aneta Hubenova (Prof.)
SYNOVO GMBH
Alemania
Aportación de la UE
€ 316 800
Dirección
Paul Ehrlich Str 15
72076 Tuebingen

Ver en el mapa

Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Michael Burnet (Mr.)
ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO
Portugal
Aportación de la UE
€ 280 800
Dirección
Campus De Azurem Universidade Do Minho
4800 058 Guimaraes

Ver en el mapa

Tipo de actividad
Other
Contacto administrativo
Artur Cavaco (Prof.)
DI DR ANDREAS PAAR KG
Austria
Aportación de la UE
€ 299 870
Dirección
Leechgasse 55/8
8010 Graz

Ver en el mapa

Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Andreas Paar (Dr.)
PRONEFRO - PRODUTOS NEFROLOGICOS SA
Portugal
Aportación de la UE
€ 164 240
Dirección
Rua B - Sector Vii Lote 98
4470-436 Maia

Ver en el mapa

Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Assunção Assunção Mascarenhas (Ms.)
DEGANIA SILICONE LTD
Israel
Aportación de la UE
€ 182 700
Dirección
Kibbutz Degania Bet
15130 Kibbutz Degania B

Ver en el mapa

Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Oded Stein (Mr.)
OSM-DAN LTD
Israel
Aportación de la UE
€ 219 410
Dirección
19 Pro Neeman Yuval St
7608665 Rehovot

Ver en el mapa

Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Pnina Dan (Dr.)
TECHNISCHE UNIVERSITAET GRAZ

La participación finalizó

Austria
Aportación de la UE
€ 33 877,62
Dirección
Rechbauerstrasse 12
8010 Graz
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Michaela Pressnig (Dr.)