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Developmental Origins of Healthy and Unhealthy Ageing: The Role of Maternal Obesity

Objective

Europe has the highest proportion of elderly people in the world. Cardiovascular disease (CVD), type 2 diabetes (T2D), sarcopenia and cognitive decline frequently coexist in the same aged individual, sharing common early risk factors and being mutually reinforcing. Obesity is a main health concern in the world. In the EU one-third of women of reproductive age are overweight and 20% are obese, a prevalence predicted to double in the next decade. There is growing evidence that maternal obesity increases the long term risk of CVD, T2D and neurodegenerative morbidity in the offspring. This project will clarify if and to what extent maternal obesity leads to premature and unhealthy ageing, by causing early, i.e. pre-/perinatal metabolic and genetic vulnerability, starting from insulin resistance and glucocorticoid exposure, leading to oxidative-stress, telomere/DNA damage, epigenetic changes, interacting with genetic and environmental variability, resulting in altered gene expression/repair, and ultimately in disease during life and pathological ageing. We will investigate the postulated mechanisms during pregnancy and development, their life long consequences in animal models and in large human cohorts followed from prenatal life until ageing, and the possibility to intervene when the condition is still reversible. Surrogate markers to estimate early risk and monitor progression-regression will be defined. This project will comprehensively address the expected impacts listed in the work programme HEALTH.2011.2.2.2-2 targeting the improvement of health and healthy ageing of a broad/broadening European population. The participation of a research intensive SME and European NGOs guarantees success in biomarker discovery-innovation and in dissemination-public preventive programs. The scientific excellence and complementariness of the partners and the relevance of the target health problem will make a highly significant impact on the European policy and research in this area.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 799 994
Administrative Contact
Michela Rial (Dr.)

Participants (9)

SAMFUNDET FOLKHALSAN I SVENSKA FINLAND RF
Finland
EU contribution
€ 600 000
Address
Topeliusgatan 20
00250 Helsinki
Activity type
Research Organisations
Administrative Contact
Christer Holmström (Mr.)
TURUN YLIOPISTO
Finland
EU contribution
€ 349 993
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eliisa Särkilahti (Dr.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 350 000
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 199 986
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Martoccia (Dr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 200 000
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Administrative Contact
Hartmut Lingner (Mr.)
BIOMOL-INFORMATICS SL
Spain
EU contribution
€ 210 000
Address
Calle Faraday -Parque Cientifico-
28049 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Milagros Ruiz Del Peso (Ms.)
European Association for the Study of Obesity
United Kingdom
EU contribution
€ 80 000
Address
High Street 113-119
TW12 1NJ Hampton Hill
Activity type
Other
Administrative Contact
Euan Woodward (Mr.)
MAKE MOTHERS MATTER EU DELEGATION
Belgium
EU contribution
€ 15 000
Address
Rue De La Gare 36
1040 Bruxelles
Activity type
Other
Administrative Contact
Marie-Claude Hayoit De Termicourt (Ms.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG
Germany
EU contribution
€ 195 000
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Ms.)