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Biomarker for Cardiovascular Risk Assessment in Europe

Objective

Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role in the drive towards personalised medicine remains uncertain.

Based on harmonised and standardised European population cohorts we have built significant research collaboration, expertise and infrastructure in the EU. We will apply highly innovative SME-driven technologies and perform large-scale biomarker determination to assess the predictive value of existing and emerging biomarkers.

Selection of emerging biomarkers will be based on integrated cutting-edge quantitative proteomic, transcriptomic, metabolomic, and miRNomic datasets established by private and public consortium members that will be disclosed to this consortium. Existing biomarkers will be selected based on non-redundancy and their association with cardiovascular risk and phenotypes. After SME-guided development of innovative assay systems biomarkers will be tested and validated in a stepwise fashion among European populations in primary and secondary prevention. In addition to their impact on risk prediction, their association with lifestyle determinants and cardiovascular phenotypes assessed by ultrasound and MRI technique will be evaluated.

We will establish a BiomarCaRE panel which leads to improved disease prediction among different European populations. International collaborations with world-class clinical trial investigators will add data on the interaction of the BiomarCaRE panel with risk-lowering medication and lifestyle changes. The outcome of SME-driven technology development and clinical validation will undergo a medical technology assessment. The determination of cost-effectiveness will guide further clinical evaluation. These studies will reveal new methods of improved cardiovascular risk estimation and will open the path towards personalised medicine.
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Coordinator

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Address

Martinistrasse 52
20251 Hamburg

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 255 925

Administrative Contact

Tanja Zeller (Dr.)

Participants (29)

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TERVEYDEN JA HYVINVOINNIN LAITOS

Finland

EU Contribution

€ 737 440

CAVADIS BV

Netherlands

EU Contribution

€ 867 880

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 105 780

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 52 320

BIOCRATES LIFE SCIENCES AG

Austria

EU Contribution

€ 372 560

UNIVERSITAT ZU LUBECK

Germany

EU Contribution

€ 266 700

UMIT- PRIVATE UNIVERSITAT FUER GESUNDHEITSWISSENSCHAFTEN, MEDIZINISCHEINFORMATIK UND TECHNIK GMBH

Austria

EU Contribution

€ 148 080

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

EU Contribution

€ 110 000

FLEET BIOPROCESSING LIMITED

United Kingdom

EU Contribution

€ 576 800

BIOCARTIS SA

Switzerland

EU Contribution

€ 291 890

RESEARCH NETWORK SERVICES LIMITED

United Kingdom

EU Contribution

€ 240 000

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ

Germany

EU Contribution

€ 57 876

UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET

Norway

EU Contribution

€ 84 084

UNIVERSITA CATTOLICA DEL SACRO CUORE

Italy

EU Contribution

€ 56 212

UNIVERSITAET GREIFSWALD

Germany

EU Contribution

€ 67 376

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 81 136

THE QUEEN'S UNIVERSITY OF BELFAST

United Kingdom

EU Contribution

€ 55 910

INSTITUT PASTEUR DE LILLE FONDATION

France

EU Contribution

€ 53 945

Consorci Institut Catala de Ciències Cardiovasculars

Spain

EU Contribution

€ 30 310

UMEA UNIVERSITET

Sweden

EU Contribution

€ 48 703

TARTU ULIKOOL

Estonia

EU Contribution

€ 74 911

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 63 773

UNIVERSITA DEGLI STUDI DELL'INSUBRIA

Italy

EU Contribution

€ 75 239

UNIVERSITY OF DUNDEE

United Kingdom

EU Contribution

€ 68 523

UNIVERSITATSSPITAL BASEL

Switzerland

EU Contribution

€ 39 858

UNIVERSITAET ULM

Germany

EU Contribution

€ 46 418

HAMILTON HEALTH SCIENCES CORPORATION

Canada

THE UNIVERSITY OF SYDNEY

Australia

EU Contribution

€ 51 324

INSTITUTO NEUROLOGICO MEDITERRANEO- NEUROMED SRL

Italy

EU Contribution

€ 19 027

Project information

Grant agreement ID: 278913

Status

Closed project

  • Start date

    1 October 2011

  • End date

    31 March 2016

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 847 985,52

  • EU contribution

    € 6 000 000

Coordinated by:

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Germany