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Genetic and environmental factors of insulin resistance syndrome and its long-term complications in immigrant Mediterranean populations

Objectif

MEDIGENE project will study genetic and environmental (G x E) determinants of the metabolic syndrome (MetS) in recent immigrants in Europe by a novel approach integrating ancestry of Mediterranean populations in epidemiology, locus refining and Genome Wide Association Studies (GWAS). West Mediterranean shores are place of pre-historical termini of population expansion from Southern Europe and North Africa. Archaeogenetic studies in Europe indicated that Y chromosome and mitochondrial DNA patterns or Ancestry Informative Markers (AIMs) revealed a close relationship between genetic and geographic distances able to locate an individual DNA within few hundred kilometers. The project will use this information in mapping the genetic basis of insulin resistance, cardiovascular and metabolic complications in immigrants (Albanians, Romanians, Turkish, Tunisians, Algerians and Morocco) in host countries France, Spain, Italy and Greece. Ancestry markers and studies on ancient DNA from Roman historical migration in Catalonia will help to give a better picture of the genetic landscape of Europe and North Africa. Genes for MetS will be studied in existing samples from host and home countries by GWAS, locus refining by next-generation sequencing and haplotype mapping. Informative filtered SNPs will be then used in epidemiology and novel DNA samples to reveal G x E interactions and specificities of the pathogenesis of MetS. Genetic findings will be replicated in home countries (Anatolia and North Africa) in the goal to develop markers ethnic specific and significant at a clinical scale. Major impact is expected from dissemination of our findings to prevent the occurrence of MetS and obesity in children and adolescents or in descendants of modern immigration, understanding variability clinical manifestations of MetS in the context of malnutrition and from the novel approach of GWAS strategies by ameliorating the association signal and bursting R&D activities of SMEs.

Appel à propositions

FP7-HEALTH-2011-two-stage
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Coordinateur

UNIVERSITE DE MONTPELLIER
Adresse
Rue Auguste Broussonnet 163
34090 Montpellier
France
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 326 427
Contact administratif
Christophe Normand (Mr.)

Participants (22)

UNIVERSITE MONTPELLIER I

Participation terminée

France
Contribution de l’UE
€ 681 736
Adresse
Boulevard Henri Iv 5
34967 Montpellier
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Christophe Normand (Mr.)
UNIVERSITE LYON 1 CLAUDE BERNARD
France
Contribution de l’UE
€ 84 000
Adresse
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Javier Olaiz (Dr.)
CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Espagne
Adresse
Calle Monforte De Lemos 5
28029 Madrid
Type d’activité
Research Organisations
Contact administratif
Ana Bosch (Ms.)
CENTRO DE INVESTIGACION BIOMEDICA EN RED DE DIABETES Y ENFERMEDADES METABOLICAS

Participation terminée

Espagne
Contribution de l’UE
€ 260 301
Adresse
Passeig De La Bonanova 69 - 6A Planta
08017 Barcelona
Type d’activité
Research Organisations
Contact administratif
Ana Bosch (Ms.)
Institut Català d'Arqueologia Clàssica
Espagne
Contribution de l’UE
€ 110 940
Adresse
Plaça Rovellat S/n
43003 Tarragona
Type d’activité
Research Organisations
Contact administratif
Josep Maria Macias Sole (Dr.)
UNIVERSITATEA DE MEDICINA SI FARMACIE CAROL DAVILA DIN BUCURESTI
Roumanie
Contribution de l’UE
€ 132 614
Adresse
Dionisie Lupu 37
020021 Bucuresti
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Mihail Coculescu (Prof.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italie
Contribution de l’UE
€ 161 940
Adresse
Via Zamboni 33
40126 Bologna
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Renato Pasquali (Prof.)
UNIVERSITA DEGLI STUDI MAGNA GRAECIA DI CATANZARO
Italie
Contribution de l’UE
€ 96 912
Adresse
Viale Europa Localita Germaneto
88100 Catanzaro
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Giorgio Sesti (Prof.)
FONDAZIONE CASA SOLLIEVO DELLA SOFFERENZA
Italie
Contribution de l’UE
€ 114 000
Adresse
Viale Cappuccini Sc
71013 San Giovanni Rotondo Fg
Type d’activité
Research Organisations
Contact administratif
Michele Giuliani (Dr.)
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italie
Contribution de l’UE
€ 150 000
Adresse
Via Cracovia 50
00133 Roma
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Davide Lauro (Prof.)
PANEPISTIMIO IOANNINON
Greece
Contribution de l’UE
€ 190 800
Adresse
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Georgios Detsikas (Mr.)
INSTITUTE OF BIOCHEMISTRY AND GENETICS, UFA SCIENTIFIC CENTRE OF RAS
Russie
Contribution de l’UE
€ 87 705
Adresse
Prospekt Oktyabrya 71
450054 Ufa
Type d’activité
Research Organisations
Contact administratif
Elza Khusnutdinova (Prof.)
INSTITUT PASTEUR DE TUNIS
Tunisie
Contribution de l’UE
€ 151 680
Adresse
Place Pasteur 13
1002 Tunis
Type d’activité
Research Organisations
Contact administratif
Sonia Abdelhak (Prof.)
UNIVERSITE D'ALGER 1
Algérie
Contribution de l’UE
€ 67 448
Adresse
Rue Didouche Mourad 02
016000 Alger
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Mahmoud Benali Abdallah (Prof.)
Institut Pasteur Du Maroc
Maroc
Contribution de l’UE
€ 63 195
Adresse
Place Louis Pasteur 1
20360 Casablanca
Type d’activité
Research Organisations
Contact administratif
Abdelhamid Barakat (Dr.)
UNIVERSITETI I TIRANES

Participation terminée

Albanie
Adresse
Boulevard Zogui
1000 Tirana
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Agron Ylli (Prof.)
BIOCOMPUTING PLATFORMS LTD OY
Finlande
Contribution de l’UE
€ 133 854
Adresse
Innopoli 3 Vaisalantie 6
02130 Espoo
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Timo Kanninen (Mr.)
PERSONMED KFT

Participation terminée

Hongrie
Adresse
Mora Ferenc Utca 50 1 Em
7632 Pecs
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Robert Hermann (Dr.)
ISTANBUL UNIVERSITESI
Turquie
Contribution de l’UE
€ 71 635
Adresse
Istanbul Universitesi Center Campus Beyazit Eminonu
34452 Istanbul
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Yildiz Tutuncu (Dr.)
Intactile SAS
France
Contribution de l’UE
€ 50 880
Adresse
20 Rue Du Carre Du Roi
34000 Montpellier
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Louis Ollagnon (Mr.)
INSTITUT ZA ANTROPOLOGIJU
Croatie
Contribution de l’UE
€ 14 940
Adresse
Ljudevita Gaja 32
10000 Zagreb
Type d’activité
Research Organisations
Contact administratif
Morana Jarec (Mrs.)
UNIVERSITETI I MJEKESISE TIRANE
Albanie
Contribution de l’UE
€ 45 900
Adresse
Rruga E Dibres 371
1005 Tirana
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Visar Sylaj (Dr.)