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Long-term effects of early nutrition on later health

Objective

Nutrition during early development has an important impact on later health, particularly through greater obesity risk, as demonstrated by FP6 EARNEST. EarlyNutrition explores the current key hypotheses on likely causes and pathways to prevention of early life origins of obesity (specifically adiposity) and associated disorders. We bring extraordinary expertise and study populations of 470,000 individuals to investigate:
• The fuel mediated in utero hypothesis
• The accelerated postnatal weight gain hypothesis
• The mismatch hypothesis.
Scientific and technical expertise in placental biology, epigenetics and metabolomics will provide understanding at the cellular and molecular level, and refined strategies for intervention in pregnancy and early post natal life to prevent obesity.
Using existing cohort studies, ongoing and novel intervention studies and a basic science programme, we will provide the scientific foundations for evidence based recommendations for optimal EarlyNutrition that incorporate long-term health outcomes, focusing on 4 Target Groups: women before pregnancy; pregnant women; infants (incl. breastfeeding); young children.
Evidence is produced from animal and placental studies (Theme 1; T1), prospective cohort studies (T2), and randomised controlled trials in pregnant women and infants (T3). T4 covers scientific strategic integration, recommendation development and dissemination, including systematic reviews and behaviour change approaches.
A strong multi-disciplinary team of international leaders in the field including collaborators from USA and Australia achieves balance and complementarity.
The project’s impact comprises definitive evidence on early nutrition effects on health, enhanced EU and global policies, major economic benefits through obesity prevention and value-added nutritional products, and practical recommendations on optimal nutrition in Target Groups. Wide dissemination will be achieved through active engagement with stakeholders.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Address

Geschwister Scholl Platz 1
80539 Muenchen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 763 722,19

Administrative Contact

Berthold Koletzko (Prof.)

Participants (39)

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KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 1 117 127

MEDIZINISCHE UNIVERSITAT GRAZ

Austria

EU Contribution

€ 388 200

STATENS SERUM INSTITUT

Denmark

EU Contribution

€ 161 400

UNIVERSIDAD DE MURCIA

Spain

EU Contribution

€ 155 729

THE UNIVERSITY OF NOTTINGHAM

United Kingdom

EU Contribution

€ 59 520

FOLKEHELSEINSTITUTTET

Norway

EU Contribution

€ 150 115

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 509 720

VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Netherlands

UNIVERSITAT ROVIRA I VIRGILI

Spain

EU Contribution

€ 165 240

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 252 120

UNIVERSITY OF SOUTHAMPTON

United Kingdom

EU Contribution

€ 977 264

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 185 800

UNIVERSIDAD DE GRANADA

Spain

EU Contribution

€ 262 140

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 223 698,74

WARSZAWSKI UNIWERSYTET MEDYCZNY

Poland

EU Contribution

€ 103 300

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 284 100

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Ireland

EU Contribution

€ 131 688

UNIVERSITA DEGLI STUDI DI MILANO

Italy

EU Contribution

€ 111 060

INSTYTUT POMNIK CENTRUM ZDROWIA DZIECKA

Poland

EU Contribution

€ 118 380

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON

Greece

EU Contribution

€ 25 680

UNIVERSITE LIBRE DE BRUXELLES

Belgium

EU Contribution

€ 2 724,22

MEDSCINET UK LTD

United Kingdom

EU Contribution

€ 234 579

GENOMIC INVESTMENTS BV

Netherlands

BIOLUTION GMBH

Austria

EU Contribution

€ 96 561,82

NIZO FOOD RESEARCH BV

Netherlands

EU Contribution

€ 63 806,25

NUTRICIA RESEARCH BV

Netherlands

BENEO GMBH

Germany

ABBOTT LABORATORIES SA

Spain

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

United States

HARVARD PILGRIM HEALTH CARE INC CORP

United States

THE UNIVERSITY OF TEXAS SYSTEM

United States

CASE WESTERN RESERVE UNIVERSITY CORPORATION - CWRU

United States

TELETHON INSTITUTE FOR CHILD HEALTH RESEARCH

Australia

MURDOCH CHILDRENS RESEARCH INSTITUTE

Australia

THE UNIVERSITY OF ADELAIDE

Australia

CENTRE HOSPITALIER CHRETIEN ASBL

Belgium

EU Contribution

€ 74 315,78

STICHTING VU

Netherlands

STICHTING VUMC

Netherlands

EU Contribution

€ 246 380

GenomeScan B.V.

Netherlands

EU Contribution

€ 98 400

Project information

Grant agreement ID: 289346

Status

Closed project

  • Start date

    1 February 2012

  • End date

    31 October 2017

Funded under:

FP7-KBBE

  • Overall budget:

    € 11 597 678,02

  • EU contribution

    € 8 962 771

Coordinated by:

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

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