Objectif Among the most fundamental objectives in modern brain research is the identification of the basic processes and mechanisms responsible for information processing, learning and memory. Many different hypotheses and conflicting models for this unsolved issue have been proposed, however, there is a wide consensus in the field that changes in synaptic connections among neurons in a network play a crucial role. Animal experiments over a period of 30 years have shown that changes in synaptic conductivity depend in a precise way on the time difference between action potentials in presynaptic and postsynaptic cells. This effect has been called spike-time dependent plasticity (STDP). The final aim of the present project will be to uncover the role of spike-time synaptic plasticity in synchronization and information transport in single units and in small neuronal networks. The approach will be mainly theoretical but it will build on experimental measurements of single neurons from the rat cortex using the dynamic clamp recording technique. By combining neurobiology, computational modelling, nonlinear dynamics and time series analysis, the origin of robustness and flexibility will be investigated at three different levels of organization: from the smallest identified neuronal subcircuits via individual neurons up to small microcircuits made up of a limited number of neurons and synapses. Champ scientifique natural sciencesbiological sciencesneurobiologynatural sciencescomputer and information sciencesdata sciencedata processing Mots‑clés Dynamics Time Inhibitory Spike analysis cl recordings modeling Nonlinear networks Computational series synapses Dynamical synchronization Neuronal train Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Appel à propositions FP6-2005-MOBILITY-6 Voir d’autres projets de cet appel Régime de financement OIF - Marie Curie actions-Outgoing International Fellowships Coordinateur CONSIGLIO NAZIONALE DELLE RICERCHE - ISTITUTO DEI SISTEMI COMPLESSI Contribution de l’UE Aucune donnée Adresse Piazzale Aldo Moro, 7 ROMA Italie Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INSTITUTE FOR NONLINEAR SCIENCE, UNIVERSITY OF CALIFORNIA, SAN DIEGO États-Unis Contribution de l’UE Aucune donnée Adresse 9500 Gilman Drive LA JOLLA Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
