Objectif Since the completion of the human and other organisms' genome sequence, many new druggable targets are expected to be identified by structural genomics with the expectation of developing new therapeutics. One of the bottlenecks of this drug discovery process is the difficulties encountered to understand the function of these new proteins. So far, much emphasis has been given to bioinformatics: the genomes are annotated using sequence analysis or structural modelling. However, these methods are not always applicable or relevant. This proposal suggests to investigate methods derived from chemoinformatics. Specifically, chemogenomics implies that the function of a protein can be derived from the structure of the sets of ligands that bind to it. By comparing the pair-wise similarity of these sets of compounds to random distributions, statistical models can be used to compute scores between pairs of sets. These scores are then used to build chemical relationship maps, i.e. ontology of the ligands. These maps could be used alternatively or complementarily to other classifications to annotate the genomes. Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencescomputer and information sciencesknowledge engineeringontologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesmathematicsapplied mathematicsstatistics and probabilitynatural sciencesbiological sciencesgeneticsgenomes Mots‑clés ANNOTATION CHEMOGENOMICS DOCKING PROTEIN SCREENING VIRTUAL Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Appel à propositions FP6-2005-MOBILITY-6 Voir d’autres projets de cet appel Régime de financement OIF - Marie Curie actions-Outgoing International Fellowships Coordinateur UNIVERSITé DE STRASBOURG Contribution de l’UE Aucune donnée Adresse 4, rue Blaise Pascal STRASBOURG France Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITY OF CALIFORNIA, SAN FRANCISCO États-Unis Contribution de l’UE Aucune donnée Adresse 1700 17th StreetRoom 508D Box 2550 2550 SAN FRANCISCO Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée