Obiettivo The proposed research plans to understand the relationship between structural requirements for TCR/peptide/MHC interactions and their influence on TCR repertoire diversity given it has been reported that increased T cell repertoire diversity correlates with increased resistance to viral infection. While the structural characteristics of TCR/peptide/MHC interactions can be elucidated, a large question that remains is how these factors influence the function of virus-specific CTL generated after infection. This proposal aims to first study the molecular interactions that define specific TCR recognition of both DbNP366 and DbPA224 complexes (respiratory infection of C57BL/6J (H-2b) mice with influenza A viruses induces CD8+ T cell responses specific for epitopes derived from nucleoprotein amino acid 366-374 and acidic polymerase amino acid 224-233 with structural and functional differences). The second aim utilises a retroviral transduction system to ectopically express TCRs of known specificity. This will facilitate the analysis of functional characteristics of these transduced T cells after infection. In this way, this proposal will link the structural aspects of TCR recognition of peptide/MHC complexes and the in vivo consequences these interactions have on the responding T cell repertoire. These studies will provide a rationale for vaccine design human viral pathogens such as HIV, Hepatitis C and Influenza A virus. Campo scientifico natural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVnatural scienceschemical sciencesorganic chemistryamines Parole chiave A CD8+ Cytotoxic T cell cell Influenza disease model receptor repertoire Mice virus T Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Invito a presentare proposte FP6-2005-MOBILITY-6 Vedi altri progetti per questo bando Meccanismo di finanziamento OIF - Marie Curie actions-Outgoing International Fellowships Coordinatore INSTITUT NATIONAL DE LA SANTÃ'© ET DE LA RECHERCHE MÃ'©DICALE Contributo UE Nessun dato Indirizzo 63 QUAI MAGELLAN HALL B 32116 NANTES Francia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto THE UNIVERSITY OF MELBOURNE Australia Contributo UE Nessun dato Indirizzo Royal Parade, Parkville, Victoria MELBOURNE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato