Objective Large full-thickness skin defects resulting from burns, soft tissue trauma, congenital giant nevi, tumour resection, and disease leading to skin necrosis, represent a significant and common clinical problem worldwide. This problem is far from being solved. The main challenge encountered is that most autologous skin grafting techniques are based on transplanting split-thickness skin (the today’s gold standard). Split-thickness skin contains all of the epidermis, but only remnants of the dermis. This lack of dermal tissue, frequently leads to significant scarring. Consequently, a true dermal substitute is required, which instantly exerts the cell-instructive properties of a neo-dermis. The partners of EuroSkinGraft can now offer 2 dermal substitutes, Novomaix and denovoDerm, plus the dermo-epidermal skin substitute denovoSkin. The development of all 3 substitutes was significantly supported by the FP6-program (EuroSTEC). The envisaged clinical studies are aiming strictly at a one-step surgical procedure (instead of the common two-step procedure, using Integra Artificial Skin).This is to be reached with the following protocol:Clinical application of Novomaix1. Experimental arm 1: split-thickness skin on Novomaix applied on full-thickness wounds2. Reference arm 1: split-thickness skin applied directly on the wound bedClinical application of denovoDerm1. Experimental arm 1: split-thickness skin on denovoDerm applied on full-thickness wounds2. Reference arm 1: split-thickness skin applied directly on the wound bedClinical application of denovoSkin1. Experimental arm 1: denovoSkin applied on full-thickness wounds2. Reference arm 1: split-thickness skin applied directly on the wound bedThe strength of this project lies in: the high degree to which real regenerative medicine is translated into the clinic, the innovative and highly functional character of the 3 products to be tested, the central contribution of the 3 SMEs, and the excellence of the 3 clinics. Fields of science medical and health sciencesmedical biotechnologytissue engineering Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.1.4-1 - Regenerative medicine clinical trials Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITAT ZURICH EU contribution € 3 020 144,34 Address RAMISTRASSE 71 8006 Zurich Switzerland See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Ernst Reichmann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG Netherlands EU contribution No data Address De Boelelaan 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Margreet Verweij-Deddens Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VEREIN FUER BERUFSGENOSSENSCHAFTLICHE HEILBEHANDLUNG BERLIN EV Germany EU contribution € 726 060,00 Address WARENER STRASSE 7 12683 BERLIN See on map Activity type Research Organisations Administrative Contact Dirk Stengel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 425 580,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Wim Van Oijen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MATRICEL GMBH Germany EU contribution € 302 520,00 Address KAISERSTRASSE 100 52134 HERZOGENRATH See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ingo Heschel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE MEDICAL DEVICE CO LTD United Kingdom EU contribution € 402 930,00 Address KAY PARK CRESCENT 42 KA3 7BA KILMARNOCK See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jeremy Francis Donnan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Participation ended Germany EU contribution € 209 919,76 Address OSKAR VON MILLER RING 29 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Fuchs (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING AMSTERDAM UMC Netherlands EU contribution € 874 852,00 Address DE BOELELAAN 1117 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Cerdic Van Der Meulen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARTTIC France EU contribution € 34 011,90 Address 39 RUE DES MATHURINS 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martin Dietz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING VU Participation ended Netherlands EU contribution No data Address DE BOELELAAN 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Margreet Verweij-Deddens Links Contact the organisation Opens in new window Website Opens in new window Total cost No data