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International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research

Objective

Though survival of children with acute lymphoblastic leukaemia (ALL) has improved, relapse remains a leading cause of mortality in childhood cancer. Given the rarity of the disease, only a large international cooperative group can recruit sufficient patients for prospective studies with specific questions in biologic subgroups. Under the umbrella of the I-BFM SG all relevant mainly European study groups are creating the worldwide largest Study for Children with Relapsed ALL (IntReALL 2010). The aim is to develop optimized standard treatment as platform for systematic randomized phase II and III studies on the most promising new and targeted agents. An adequate trial structure, an optimized web based database, and standardized diagnostic methods need to be established.
Patients are stratified into a standard (SR) and a high risk (HR) group according to established factors. For SR patients, the best available treatment protocols ALL-REZ BFM 2002 and ALL R3 are randomly compared, and the additional effect on survival of the humanized monoclonal CD22 directed antibody epratuzumab is investigated. HR patients who have unsatisfying remission rates will receive an intensified induction with the proteasome inhibitor bortezomib randomly combined with standard induction therapy. IntReALL 2010 allows for comprehensive tumour banking and systematic biologic research in subgroups with correlation to clinical outcome. SMEs will be involved into project management, data base development, and pharmaceutical and biotechnological research to ensure innovation in the respective areas. IntReALL 2010 is embedded in a network of European academic structures relevant for childhood cancer. It will be a cornerstone of drug development in childhood leukaemia and the only trial with the potential for well powered phase III studies in this indication. IntReALL 2010 will harmonize ALL-relapse therapy, establish highest diagnostic and therapeutic standard and improve survival of children with ALL.

Field of science

  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Address
Chariteplatz 1
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 111 501,25
Administrative Contact
Eveline Fräßdorf (Ms.)

Participants (28)

CONFEDERACION INTERNACIONAL DE ORGANIZACIONES DE PADRES DE NINOS CON CANCER ASOCIACION

Participation ended

Spain
EU contribution
€ 53 906,25
Address
Plaza Pablo Picasso 9 3 D
46015 Valencia
Activity type
Other
Administrative Contact
Patricia Brouwer (Dr.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 146 700
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Jean-Pierre Bourquin (Dr.)
FAKULTNI NEMOCNICE V MOTOLE
Czechia
EU contribution
€ 167 420
Address
V Uvalu 84
150 06 Praha 5
Activity type
Research Organisations
Administrative Contact
Lucie Sramkova (Dr.)
ST. ANNA KINDERKREBSFORSCHUNG
Austria
EU contribution
€ 146 700
Address
Zimmermannplatz 10
1090 Wien
Activity type
Research Organisations
Administrative Contact
Karla María Valdés Rodríguez (Prof.)
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON

Participation ended

France
EU contribution
€ 118 848
Address
Place Saint Jacques 2
25030 Besancon Cedex
Activity type
Research Organisations
Administrative Contact
Stephanie François (Ms.)
INSTITUTO PORTUGUES DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL EPE
Portugal
EU contribution
€ 95 400
Address
Rua Professor Lima Basto
1099 023 Lisboa
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Nuno Alexandre Fernandes Arez (Dr.)
ASSOCIATION HOSPITALIERE DE BRUXELLES - HOPITAL UNIVERSITAIRE DES ENFANTS REINE FABIOLA - ASSOCIATION HOSPITALIERE HUDERF
Belgium
EU contribution
€ 10 000
Address
Avenue Jean-joseph Crocq 15
1020 Bruxelles
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Alina Ferster (Prof.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 241 500
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Walstam (Mr.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 87 500
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Thomas Frandsen (Dr.)
VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
EU contribution
€ 146 700
Address
Kiinamyllynkatu 4-8
20520 Turku
Activity type
Research Organisations
Administrative Contact
Jari-Pekka Tuominen (Mr.)
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 102 300
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marit Hellebostad (Dr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 559 940
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katherine Boylan (Dr.)
STICHTING KATHOLIEKE UNIVERSITEIT

Participation ended

Netherlands
EU contribution
€ 12 709,20
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maarten Van Langen (Mr.)
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
EU contribution
€ 516 067,50
Address
Piazza Sant Onofrio 4
00165 Roma
Activity type
Other
Administrative Contact
Sonya Jane Martin (Dr.)
THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV
Israel
EU contribution
€ 140 700
Address
Weizmann Street 6
64239 Tel Aviv
Activity type
Research Organisations
Administrative Contact
Ronit Elhasid (Dr.)
UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU
Poland
EU contribution
€ 286 700
Address
Ul Pasteura 1
50 367 Wroclaw
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ewa Gorczynska (Prof.)
CHILDHOOD CANCER INTERNATIONAL
Netherlands
Address
Schouwstede 2B
3431 JB Nieuwegein
Activity type
Other
Administrative Contact
Patricia Brouwer (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 133 500
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 188 350
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
IMMUNOMEDICS INC. CORPORATION
United States
EU contribution
€ 235 800
Address
American Road 300
07950 Morris Plains
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heather Horne (Ms.)
XCLINICAL GMBH
Germany
EU contribution
€ 222 000
Address
Arnulfstrasse 19
80335 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Verena Frank
POPULATION GENETICS TECHNOLOGIES LTD

Participation ended

United Kingdom
EU contribution
€ 1 462,44
Address
Babraham Research Campus
CB22 3AT Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Conrad Lichtenstein (Prof.)
TP21 GMBH
Germany
EU contribution
€ 345 600
Address
Luisenstrasse 14
10117 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hanno Wittig (Dr.)
EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL
Belgium
EU contribution
€ 210 218
Address
Avenue E. Mounier 83
1200 Brussels
Activity type
Research Organisations
Administrative Contact
Stephane Lejeune (Mr.)
GENOMIC INVESTMENTS BV

Participation ended

Netherlands
EU contribution
€ 264 637,56
Address
Plesmanlaan 1D
2333 BZ Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pascal Berserik (Mr.)
CENTRE HOSPITALIER UNIVERSITAIRE DE NICE
France
EU contribution
€ 178 704
Address
Avenue Victoria 4
06003 Nice
Activity type
Research Organisations
Administrative Contact
Laura Giustiniani (Mrs.)
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
EU contribution
€ 273 190,80
Address
Heidelberglaan 25
3584CS Utrecht
Activity type
Other
Administrative Contact
Menno Beerens (Mr.)
GenomeScan B.V.
Netherlands
Address
Plesmanlaan 1D
2333 BZ Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juliëtte Both