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Integrating high performance mass spectrometry tools with application in life science

Objective

Recent advances of biopolymer mass spectrometry - first highlighted by the Nobel Prize-awarded “soft ionization” methods - have opened new applications in life sciences, such as the identification of proteins from complex biological material (proteomics). A number of high performance mass spectrometry technologies and hyphenated separation methods have become amenable; however, their efficient exploration and integration in interdisciplinary biochemical and biomedical applications is still in the initial phase. In this project an effective exchange scheme of staff will be established between European laboratories of different application areas, and leading American Centers of high performance biopolymer mass spectrometry. Joint research projects through exchange of coworkers will focus on the determination of protein structures and pathophysiological structure modifications; the identification of the assembly and topology of large protein complexes; development and application of disease-related quantitative proteome analysis; characterization of protein conformations and misfolding/aggregating proteins; applications to elucidate protein-biopolymer interactions and molecular recognition structures using new tools of bioaffinity-mass spectrometry. The principal goals of this project are (i), to establish new technologies of mass spectrometry in important life science applications such as the identification of biomarkers for disease diagnostics; and (ii), to provide a basis, through exchange of coworkers, for the integration of mass spectrometry tools with biochemical and biomedical technologies. This project will contribute to (i), integrate interdisciplinary applications of biopolymer mass spectrometry in life sciences; (ii), enhance exchange and collaboration between European and North-American academic laboratories; (ii) the graduate and postgraduate education of young researchers in mass spectrometry in life sciences.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /natural sciences/chemical sciences/analytical chemistry/mass spectrometry

Call for proposal

FP7-PEOPLE-2010-IRSES
See other projects for this call

Funding Scheme

MC-IRSES - International research staff exchange scheme (IRSES)

Coordinator

UNIVERSITAT KONSTANZ
Address
Universitatsstrasse 10
78464 Konstanz
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 100 800
Administrative Contact
Christina Leib (Ms.)

Participants (4)

UNIVERSITAET ROSTOCK
Germany
EU contribution
€ 48 300
Address
Universitatsplatz 1
18055 Rostock
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael O. Glocker (Prof.)
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 44 100
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arne Bækdal Hansen (Mr.)
UNIVERSITATEA AUREL VLAICU DIN ARAD
Romania
EU contribution
€ 52 500
Address
Bulevard Revolutiei 77
310130 Arad
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alina-Diana Zamfir (Prof.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 73 500
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Reinout Raijmakers (Dr.)