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EPIC-CVD: Individualised CVD risk assessment: tailoring targeted and cost-effective approaches to Europe's diverse populations

Objective

"EPIC-CVD's overarching goal is to provide clinicians and policy-makers with a menu of evidence-based options for cost-effective individualised risk assessment that enables the EU's increasingly resource-constrained economies to achieve more personalised predictive medicine in harmony with Europe's diverse cultures and healthcare systems.

We will achieve this through developing and validating innovative risk scores and efficient screening strategies by studying 75 high priority soluble biomarkers and 215,000 carefully selected genetic variants in the most powerful population-based prospective study ever conducted of incident coronary heart disease, stroke, and type 2 diabetes across 10 diverse European countries. EPIC-CVD will provide the first consideration across Europe of risk scores with information on the interplay of nature and nurture together with biomarkers of lifestyle, biological pathways, vascular injury, and ageing.

Our multidisciplinary consortium involves world-leading expertise in population health science, laboratory science (including VITAS, an SME partner, renowned for nutritional biomarker assays), translational science, and implementation science. This rare combination of expertise will enable systematic consideration of the implications of risk scores and screening strategies for predictive accuracy, feasibility, safety, acceptability, and cost-effectiveness. The impact on clinical decision making and clinical outcomes will be demonstrated in a new randomised trial of risk scores in relation to ""patient-centred"" outcomes that assess attitudes, behaviours, and biological risk factors.

Key stakeholders (eg, healthcare professionals, regulators, industry) will be closely engaged by the project. Policy recommendations mindful of the broader societal implications of targeted screening will be tailored to Europe's diverse needs and systematically disseminated to various audiences. This initiative will derive major synergy from related efforts."

Field of science

  • /medical and health sciences/basic medicine/neurology/stroke
  • /medical and health sciences/clinical medicine/endocrinology/diabetes

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 582 778,45
Administrative Contact
John Danesh (Prof.)

Participants (29)

VITAS AS
Norway
EU contribution
€ 1 073 697,90
Address
Gaustadalleen 21
0349 Oslo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Gundersen (Dr.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 206 684,40
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yvonne Van Der Schouw (Prof.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 59 314,80
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Olle Melander (Prof.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 411 174,30
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Nick Wareham (Prof.)
CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
France
EU contribution
€ 159 500,40
Address
150 Cours Albert Thomas
69372 Lyon Cedex 08
Activity type
Other
Administrative Contact
Maimuna Mendy (Dr.)
IIGM FOUNDATION
Italy
EU contribution
€ 23 644,80
Address
Piazza Bernini 5
10138 Torino
Activity type
Research Organisations
Administrative Contact
Giuseppe Matullo (Prof.)
DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE
Germany
EU contribution
€ 23 544
Address
Arthur-scheunert-allee 114-116
14558 Nuthetal
Activity type
Research Organisations
Administrative Contact
Heiner Boeing (Prof.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 196 416
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Palalic Tatjana (Ms.)
HELLENIC HEALTH FOUNDATION
Greece
EU contribution
€ 27 258
Address
Kaisareias 13 & Alexandroupoleos
11527 Athens
Activity type
Research Organisations
Administrative Contact
Antonia Trichopoulou (Prof.)
ESCUELA ANDALUZA DE SALUD PUBLICA SA
Spain
EU contribution
€ 145 689,75
Address
Cuesta Del Observatorio Campus Universitario De Cartuja 4
18011 Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sánchez-Pérez María-José (Dr.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 51 057,20
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dorthe Hejl Boye (Ms.)
UMEA UNIVERSITET
Sweden
EU contribution
€ 18 511,20
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Goran Hallmans (Prof.)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 9 585
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
Administrative Contact
Jolanda Maria Antoinette Boer (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 10 520,40
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tim Key (Prof.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 8 194,80
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Salvatore Panico (Dr.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 8 421
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Ina Krischek (Dr.)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
EU contribution
€ 9 111,60
Address
Via Venezian 1
20133 Milan
Activity type
Research Organisations
Administrative Contact
Vittorio Krogh (Dr.)
UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Norway
EU contribution
€ 8 173,20
Address
Hansine Hansens Veg 14
9019 Tromso
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eiliv Lund (Prof.)
ASOCIACION INSTITUTO BIODONOSTIA
Spain
EU contribution
€ 8 898
Address
Paseo Dr. Beguiristain S/n
20014 Donostia-san Sebastian
Activity type
Research Organisations
Administrative Contact
Irune Vegas (Ms.)
FUNDACION PUBLICA MIGUEL SERVET

Participation ended

Spain
Address
Calle Irunlarrea 3 Centro Investigacion Biomedica Recinto Complejo Hospitalario De Navarra
31008 Pamplona
Activity type
Research Organisations
Administrative Contact
Conchi Moreno-Iribas (Dr.)
FUNDACION PARA LA FORMACION E INVESTIGACION SANITARIAS DE LA REGION DE MURCIA
Spain
EU contribution
€ 10 222,80
Address
Calle Luis Fontes Pagan 9 Edif Emi Hospital Reina Sofia
30003 Murcia
Activity type
Research Organisations
Administrative Contact
Carmen Navarro (Dr.)
ISTITUTO PER LO STUDIO E LA PREVENZIONE E LA RETE ONCOLOGICA
Italy
EU contribution
€ 8 792,10
Address
Via Cosimo Il Vecchio 2
50139 Firenze
Activity type
Other
Administrative Contact
Domenico Palli (Dr.)
CONSEJERIA DE SALUD Y SERVICIOS SANITARIOS - Principado de Asturias
Spain
EU contribution
€ 10 020,50
Address
Ciriaco Miguel Vigil 9
33006 Oviedo
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Laudina Rodriguez (Dr.)
THE UNIVERSITY OF AUCKLAND
New Zealand
Address
Princes Street 24
1010 Auckland
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kate Harrower
RAND EUROPE COMMUNITY INTEREST COMPANY
United Kingdom
EU contribution
€ 74 750
Address
Milton Road Westbrook Centre
CB4 1YG Cambridge Cambridgeshire
Activity type
Research Organisations
Administrative Contact
Ellen Nolte (Dr.)
FOUNDATION FOR GENOMICS & POPULATION HEALTH
United Kingdom
EU contribution
€ 47 276,40
Address
Worts Causeway 2
CB1 8RN Cambridge
Activity type
Research Organisations
Administrative Contact
Hilary Burton (Dr.)
ASSOCIAZIONE IBLEA PER LA RICERCA EPIDEMIOLOGICA ONLUS
Italy
EU contribution
€ 8 387
Address
Piazza Ancione 2
97100 Ragusa
Activity type
Research Organisations
Administrative Contact
Francesco Occhipinti (Dr.)
ORGANISMO AUTONOMO INSTITUTO DE SALUD PUBLICA Y LABORAL DE NAVARRA
Spain
EU contribution
€ 8 642
Address
Cl Leyre 15
31003 Pamplona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Marisol Fragoso (Ms.)
BRAINSHAKE OY
Finland
EU contribution
€ 777 000
Address
Vuoliaistie 15
90540 Oulu
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Suna Teemu (Mr.)