Objectif Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life. Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient delivery to the needs of the developing fetus. EpiHealth will focus on these early events in several relevant models(diabetes, obesity and assisted reproductive technologies (ART)),using human samples, stem cell lines, animal models and data mining/bioinformatics tools to decipher some of the most important pathways and to offer options for early intervention to avoid adverse health effects. Main goal of the project is to improve health of the human population by understanding the mechanisms and pathways in early development, with special emphasis on epigenetic changes and developmentally relevant metabolic signalling, which create biological variation and have a long term effect on the health of individuals across the lifespan. Specific goals include: i)Identification of the main genetic pathways affecting the health of the developing embryos in a diabetic or obese maternal environment; ii) Identification of the main genetic and metabolic pathways affected and epigenomic and imprinting perturbations from mouse and human ART resulting in altered health of the progeny; iii)Discovery of the key genes and pathways affecting epigenetic and imprinting sensitivity in early stages of development in order to create intervention tools against epigenetic mis-programming; iv)Linking for the first time by bioinformatics tools the longevity related pathways and those susceptible to early epigenetic perturbations in order to explain how early events influence the health and lifespan of individuals; v)Studying the possibilities of early intervention by controlling the maternal environment. Champ scientifique medical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineembryologymedical and health scienceshealth sciencesnutritionobesitynatural sciencesbiological sciencesgeneticsepigenetics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2011.2.2.2-2 - Linking human development and ageing Appel à propositions FP7-HEALTH-2011-two-stage Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur BIOTALENTUM TUDASFEJLESZTO KFT Contribution de l’UE € 661 615,60 Adresse AULICH LAJOS UTCA 26 2100 Goedoello Hongrie Voir sur la carte Région Közép-Magyarország Pest Pest Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Andras Dinnyes (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (6) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITY OF SOUTHAMPTON Royaume-Uni Contribution de l’UE € 264 810,36 Adresse Highfield SO17 1BJ Southampton Voir sur la carte Région South East (England) Hampshire and Isle of Wight Southampton Type d’activité Higher or Secondary Education Establishments Contact administratif Yan Qiao (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Royaume-Uni Contribution de l’UE € 516 006,00 Adresse TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Voir sur la carte Région East of England East Anglia Cambridgeshire CC Type d’activité Higher or Secondary Education Establishments Contact administratif Renata Schaeffer (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG Allemagne Contribution de l’UE € 371 841,60 Adresse UNIVERSITATSPLATZ 10 6108 Halle Voir sur la carte Région Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Type d’activité Higher or Secondary Education Establishments Contact administratif Peggy Patzner (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE UNIVERSITY OF MANCHESTER Royaume-Uni Contribution de l’UE € 417 305,64 Adresse OXFORD ROAD M13 9PL Manchester Voir sur la carte Région North West (England) Greater Manchester Manchester Type d’activité Higher or Secondary Education Establishments Contact administratif Katherine Boylan (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL Allemagne Contribution de l’UE € 346 136,80 Adresse OLSHAUSENSTRASSE 40 24118 Kiel Voir sur la carte Région Schleswig-Holstein Schleswig-Holstein Kiel, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Susanne Neufeldt (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée AVANTEA SRL Italie Contribution de l’UE € 364 640,00 Adresse VIA CABRINI 12 26100 CREMONA Voir sur la carte Région Nord-Ovest Lombardia Cremona Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Cesare Galli (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée